Volumetric Modulated Arc Therapy Dose Distribution Prediction for Breast Cancer Patients: CNN Approach

This paper aims to explore popular CNN architectures for the generation of patient-specific dose distributions for Volumetric Modulated Arc Therapy (VMAT) radiotherapy satisfying clinical dose-volume constraints. Only organs at risk (OARs) and planning target volume (PTV) segmentations are required as input. The outcome of the research is selecting the optimal network architecture and assessing training parameters. The U-net, ResNet+U-net, ResNet+PSPNet networks are analyzed. The Resnet+U-net model was chosen as the most suited to the task. The similarity measures such as mIoU and mDice coefficient as well as the dose-volume constraints in PTV and selected OARs are evaluated. The results confirm that the Reset+U-net network is capable of generating patient-specific dose distribution and can be used as a valuable assistance during clinical radiotherapy planning procedures.