Effects on droplet generation in step-emulsification microfluidic devices

被引:17
作者
Liu, Ziwei [1 ]
Liu, Xiyang [1 ]
Jiang, Shaokun [2 ]
Zhu, Chunying [1 ]
Ma, Youguang [1 ]
Fu, Taotao [1 ]
机构
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] 718th Res Inst CSSC, 17 Zhanlan Rd, Handan City 056027, Hebei, Peoples R China
基金
中国国家自然科学基金;
关键词
Step emulsification; Droplet; Microchannel; Interface; Satellite droplet; HIGH-THROUGHPUT PRODUCTION; MONODISPERSE EMULSION DROPLETS; IN-OIL EMULSIONS; MICROCHANNEL EMULSIFICATION; BUBBLE FORMATION; INTERFACIAL-TENSION; SATELLITE DROPLETS; BREAKUP DYNAMICS; WATER; DRIVEN;
D O I
10.1016/j.ces.2021.116959
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Y Step emulsification technology is an important breakthrough for the industrial application of microfluidic devices. In this paper, the influences of microdevice structures and physical properties of fluids on the droplet (around 1 mm in size) generation in a step emulsificator with a single microchannel are studied. Through the analysis of the interface evolution process during droplet generation, we found that increasing the width of the terrace (0.4-1.0 mm) and the size of the collection cavity, decreasing the viscosity of the dispersed phase (0.89-54.61 mPa.s) result in the increase in the range of the dripping flow regime, obtaining a larger emulsion flux of the microdevice. The prediction equation for the droplet size is proposed by considering the inertial and viscous forces of the dispersed phase: D/h= 1.63Oh(0.17)We(0.14) + D-0/h(0.47)Oh(0.24). Finally, the relationship between the satellite droplet size formed by the neck rupture and the manipulation variables is presented. (C) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页数:15
相关论文
共 50 条
  • [41] Microfluidic Step Emulsification with Parallel Nozzles on a Vertical Slit
    Zheng, Chunqi
    Masui, Shuzo
    Kanno, Yusuke
    Nisisako, Takasi
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2024, 63 (23) : 10226 - 10233
  • [42] Formation of Droplets of Shear-Thinning Fluids in a Wedge-Shaped Step-Emulsification Microdevice
    Wang, Ting
    He, Chengxiang
    He, Tianxi
    Liu, Xiyang
    Feng, Tianyang
    Zhu, Chunying
    Ma, Youguang
    Fu, Taotao
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2023, 62 (36) : 14467 - 14477
  • [43] Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles
    Ji, Guangchong
    Kanno, Yusuke
    Nisisako, Takasi
    MICROMACHINES, 2023, 14 (03)
  • [44] Assembled Step Emulsification Device for Multiplex Droplet Digital Polymerase Chain Reaction
    Nie, Mengyue
    Zheng, Meng
    Li, Caiming
    Shen, Feng
    Liu, Manhua
    Luo, Haibei
    Song, Xiaohui
    Lan, Ying
    Pan, Jian-Zhang
    Du, Wenbin
    ANALYTICAL CHEMISTRY, 2019, 91 (03) : 1779 - 1784
  • [45] Centrifugal step emulsification applied for absolute quantification of nucleic acids by digital droplet RPA
    Schuler, Friedrich
    Schwemmer, Frank
    Trotter, Martin
    Wadle, Simon
    Zengerle, Roland
    von Stetten, Felix
    Paust, Nils
    LAB ON A CHIP, 2015, 15 (13) : 2759 - 2766
  • [46] Piezoelectric-synchronized step emulsification for facile generation of microdroplet library with fluid-independent drop size regulation regime
    Liao, Wenya
    Wu, Zhiqiang
    Liu, Li
    Lu, Qianqian
    Wang, Pengfei
    Huang, Xing
    Xu, Zhongbin
    CHEMICAL ENGINEERING JOURNAL, 2024, 493
  • [47] Monodispersed microfluidic droplet generation by shear focusing microfluidic device
    Tan, YC
    Cristini, V
    Lee, AP
    SENSORS AND ACTUATORS B-CHEMICAL, 2006, 114 (01): : 350 - 356
  • [48] Microfluidic EDGE emulsification: the importance of interface interactions on droplet formation and pressure stability
    Sahin, Sami
    Bliznyuk, Olesya
    Cordova, Ana Rovalino
    Schroen, Karin
    SCIENTIFIC REPORTS, 2016, 6
  • [49] Effects of wall velocity slip on droplet generation in microfluidic T-junctions
    Li, Xinlong
    He, Liqun
    Lv, Song
    Xu, Chi
    Qian, Peng
    Xie, Fubo
    Liu, Minghou
    RSC ADVANCES, 2019, 9 (40) : 23229 - 23240
  • [50] Advancements in microfluidic droplet generation: methods and insights
    Das, Shobhit
    Unni, Harikrishnan Narayanan
    MICROFLUIDICS AND NANOFLUIDICS, 2025, 29 (04)