Prenatal undernutrition and cognitive function in late adulthood

被引:225
作者
de Rooij, Susanne R. [1 ]
Wouters, Hans [1 ]
Yonker, Julie E. [3 ]
Painter, Rebecca C. [2 ]
Roseboom, Tessa J. [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, NL-1100 DD Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Gynaecol, NL-1100 DD Amsterdam, Netherlands
[3] Calvin Coll, Dept Psychol, Grand Rapids, MI 49546 USA
基金
英国医学研究理事会;
关键词
developmental origins; fetal; nutrition; cognition; aging; VASCULAR RISK-FACTORS; WHITE-MATTER LESIONS; FAMINE; SCHIZOPHRENIA; EXPOSURE; INTERFERENCE; PERFORMANCE; ATTENTION; DISORDER; DISEASE;
D O I
10.1073/pnas.1009459107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
the end of World War II, a severe 5-mo famine struck the cities in the western part of The Netherlands. At its peak, the rations dropped to as low as 400 calories per day. In 1972, cognitive performance in 19-y-old male conscripts was reported not to have been affected by exposure to the famine before birth. In the present study, we show that cognitive function in later life does seem affected by prenatal undernutrition. We found that at age 56 to 59, men and women exposed to famine during the early stage of gestation performed worse on a selective attention task, a cognitive ability that usually declines with increasing age. We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process.
引用
收藏
页码:16881 / 16886
页数:6
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