Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer

被引：64
作者：
Markowska, Anna [1 ]
Sajdak, Stefan [2 ]
Markowska, Janina [3 ]
Huczynski, Adam [4 ]
机构：
[1] Karol Marcinkowski Med Univ, Dept Perinatol & Womens Dis, Poznan, Poland
[2] Karol Marcinkowski Med Univ, Dept Gynecol Surg, Poznan, Poland
[3] Karol Marcinkowski Med Univ, Dept Oncol, Poznan, Poland
[4] Adam Mickiewicz Univ, Fac Chem, Poznan, Poland
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 142卷
关键词：
Ovarian cancer; Cancer stem cells; Anti-angiogenic therapy; Metformin; Salinomycin; IN-VITRO; TUMOR ANGIOGENESIS; TARGETED TREATMENT; DRUG-RESISTANCE; METFORMIN; SALINOMYCIN; APOPTOSIS; CYTOTOXICITY; BEVACIZUMAB; MECHANISMS;
D O I：
10.1016/j.ejmech.2017.06.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Failure in ovarian cancer therapy, following cytoreduction and chemotherapy, is related to the presence of cancer stem cells - a small subpopulation of cells resistant to chemotherapy and irradiation - in the tumour which may cause cancer relapse and manifestation of metastases. Therapies targeted at Cancer Stem Cells (CSCs), such as those employing metformin (a drug used in the treatment of diabetes type II) and salinomycin, an antibiotic isolated from Streptococcus calms bacteria, seem promising. Antiangiogenic therapy with bevacizumab was found to be effective in all phases of ovarian cancer treatment. The presence of CSCs has been associated with angiogenesis. Several CSC biomarkers correlate with the markers of angiogenesis and some signalling pathways, e.g. Notch, and are used by both CSCs and by pro-angiogenic factors. (C) 2017 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：87 / 94
页数：8
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