Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+ T-cell response, prominent infiltration of CD8+ lymphocytes and Th1 type polarization

被引：45

作者：

Ranki, Tuuli ^{[1
]}

Joensuu, Timo ^{[2
]}

Jaeger, Elke ^{[3
]}

Karbach, Julia ^{[3
]}

Wahle, Claudia ^{[3
]}

Kairemo, Kalevi ^{[2
]}

Alanko, Tuomo ^{[2
]}

Partanen, Kaarina ^{[2
]}

Turkki, Riku ^{[4
]}

Linder, Nina ^{[4
]}

Lundin, Johan ^{[4
]}

Ristimaki, Ari ^{[5
,6
,7
]}

Kankainen, Matti ^{[4
]}

Hemminki, Akseli ^{[8
]}

Backman, Charlotta ^{[1
]}

Dienel, Kasper ^{[1
]}

von Euler, Mikael ^{[1
]}

Haavisto, Elina ^{[1
]}

Hakonen, Tiina ^{[1
]}

Juhila, Juuso ^{[1
]}

Jaderberg, Magnus ^{[1
]}

Priha, Petri ^{[1
]}

Vassilev, Lotta ^{[1
]}

Vuolanto, Antti ^{[1
]}

Pesonen, Sari ^{[1
]}

机构：

[1] Oncos Therapeut, Helsinki, Finland

[2] Docrates Canc Ctr, Helsinki, Finland

[3] Krankenhaus NW Frankfurt, Frankfurt, Germany

[4] Inst Mol Med Finland FIMM, Helsinki, Finland

[5] Univ Helsinki, Cent Hosp, Div Pathol, HUSLAB, Helsinki, Finland

[6] Univ Helsinki, Cent Hosp, Haartman Inst, Helsinki, Finland

[7] Univ Helsinki, Res Programs Unit, Helsinki, Finland

[8] Univ Helsinki, Haartman Inst, Canc Gene Therapy Grp, Helsinki, Finland

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 10期

关键词：

Adenovirus; antitumor immunity; cytotoxic immunotherapy; GM-CSF; Th1; polarization; tumor infiltrating lymphocytes;

D O I：

10.4161/21624011.2014.958937

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of tumor infiltrating lymphocytes (TILs) and specific gene-signatures prior to treatment are linked to good prognosis, while the opposite is true for extensive immunosuppression. The use of adenoviruses as cancer vaccines is a form of active immunotherapy to initialise a tumor-specific immune response that targets the patient's unique tumor antigen repertoire. We report a case of a 68-year-old male with asbestos-related malignant pleural mesothelioma who was treated in a Phase I study with a granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing oncolytic adenovirus, Ad5/3-D24-GMCSF (ONCOS-102). The treatment resulted in prominent infiltration of CD8(+) lymphocytes to tumor, marked induction of systemic antitumor CD8C T-cells and induction of Th1-type polarization in the tumor. These results indicate that ONCOS-102 treatment sensitizes tumors to other immunotherapies by inducing a T-cell positive phenotype to an initially T-cell negative tumor.

引用

页码：e958937 / 1

页数：4

共 21 条

[21] STC1 encapsulated in small extracellular vesicles from laryngeal squamous cell carcinoma cells induces CD8+ T cell dysfunction by reprogramming tumor-associated macrophages into M2-like macrophages [J].

Chen, Xiaoxue ;

Zhao, Zhigang ;

Zhao, Rui ;

Li, Wenjing ;

Liu, Xinyu ;

Tian, Linli ;

Liu, Ming .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2025, 74 (02)

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