Construction of a Non-Enzymatic Electrochemical Sensor Based on Metal-Organic-Framework-Derived Manganese Oxide Microspheres for the Detection of Hydrogen Peroxide

It is significant to construct a non-enzymatic electrochemical sensor for accurately detecting hydrogen peroxide (H2O2) due to the relation between the concentration of H2O2 and the health of organisms. In this work, metal-organic framework (MOF)-derived manganese oxide (MnOx) microsphere were synthesized through the coordination of H3BTC and Mn2+ to form the precursor, followed by calcination. The morphologies and microstructures were characterized by using SEM, TEM, XRD and FT-IR. Furthermore, the electrochemical activity of the MnOx microsphere was studied for applications as a hydrogen peroxide sensor. The sensor was characterized by cyclic voltammetry, which showed that the material especially good electrical conductivity and catalytic performance. It also obtained a linear detection range of 6.96x10(-4)-742 mu M (S/N=3) with a limit of detection of 2.32x10(-4) mu M for the detection of H2O2. The sensor described here had a strong anti-interference ability with respect to several substances. In addition, it was applied to the H2O2 determination in human serum and milk samples with acceptable recovery, demonstrating its potential application in the conventional analysis of H2O2.