Dual-stimuli responsive nanotheranostics for mild hyperthermia enhanced inhibition of Wnt/β-catenin signaling

被引：28

作者：

Feng, Tao ^{[1
]}

Zhou, Liang ^{[2
]}

Wang, Zhongyuan ^{[2
]}

Li, Chunxiao ^{[1
]}

Zhang, Yifan ^{[1
]}

Lin, Jing ^{[1
]}

Lu, Desheng ^{[2
]}

Huang, Peng ^{[1
]}

机构：

[1] Shenzhen Univ, Marshall Lab Biomed Engn, Lab Evolutionary Theranost, Int Canc Ctr,Sch Biomed Engn,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Int Canc Ctr, Dept Pharmacol,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

来源：

BIOMATERIALS | 2020年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Nanotheranostics; Melanin coated magnetic nanoparticles; Obatoclax; Mild hyperthermia; Wnt/beta-catenin signaling pathway; DRUG-DELIVERY; CANCER; CHEMOTHERAPY; NANOPARTICLES; THERANOSTICS; COMBINATION; GRAPHENE; NANODOTS; PLATFORM; CELLS;

D O I：

10.1016/j.biomaterials.2019.119709

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Wnt/beta-catenin signaling cascade is highly associated with tumorigenesis and progression of various cancers. Targeting Wnt/beta-catenin signaling exhibits a promising way for cancer treatment. Herein, dual-stimuli responsive nanotheranostics was synthesized, which was composed of melanin coated magnetic nanoparticles (MMNs) and Wnt signaling inhibitor obatoclax (OBX) for multimodality imaging guided mild hyperthermia-enhanced chemotherapy. The MMNs could be used as contrast agents for magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) guided photothermal therapy. In addition, OBX-loaded MMNs (OBX-MMNs) were specific response to both pH changes and near-infrared (NIR) light illumination, which could trigger OBX release. Most intriguingly, tumor tissue accumulation and cellular intemalization of this nanotheranostics could be dramatically enhanced through mild hyperthermia generated by laser-irradiated MMNs. Laser irradiation exhibited efficient chemotherapeutic outcome through enhancing OBX-mediated inhibition of the Wnt/beta-catenin signaling. Our results indicated the as-prepared OBX-MMNs hold great potential for MR/PA dual-modal imaging guided mild hyperthermia-enhanced chemotherapy.

引用

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