Dual-stimuli responsive nanotheranostics for mild hyperthermia enhanced inhibition of Wnt/β-catenin signaling

被引：28

作者：

Feng, Tao ^{[1
]}

Zhou, Liang ^{[2
]}

Wang, Zhongyuan ^{[2
]}

Li, Chunxiao ^{[1
]}

Zhang, Yifan ^{[1
]}

Lin, Jing ^{[1
]}

Lu, Desheng ^{[2
]}

Huang, Peng ^{[1
]}

机构：

[1] Shenzhen Univ, Marshall Lab Biomed Engn, Lab Evolutionary Theranost, Int Canc Ctr,Sch Biomed Engn,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Int Canc Ctr, Dept Pharmacol,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

来源：

BIOMATERIALS | 2020年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Nanotheranostics; Melanin coated magnetic nanoparticles; Obatoclax; Mild hyperthermia; Wnt/beta-catenin signaling pathway; DRUG-DELIVERY; CANCER; CHEMOTHERAPY; NANOPARTICLES; THERANOSTICS; COMBINATION; GRAPHENE; NANODOTS; PLATFORM; CELLS;

D O I：

10.1016/j.biomaterials.2019.119709

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Wnt/beta-catenin signaling cascade is highly associated with tumorigenesis and progression of various cancers. Targeting Wnt/beta-catenin signaling exhibits a promising way for cancer treatment. Herein, dual-stimuli responsive nanotheranostics was synthesized, which was composed of melanin coated magnetic nanoparticles (MMNs) and Wnt signaling inhibitor obatoclax (OBX) for multimodality imaging guided mild hyperthermia-enhanced chemotherapy. The MMNs could be used as contrast agents for magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) guided photothermal therapy. In addition, OBX-loaded MMNs (OBX-MMNs) were specific response to both pH changes and near-infrared (NIR) light illumination, which could trigger OBX release. Most intriguingly, tumor tissue accumulation and cellular intemalization of this nanotheranostics could be dramatically enhanced through mild hyperthermia generated by laser-irradiated MMNs. Laser irradiation exhibited efficient chemotherapeutic outcome through enhancing OBX-mediated inhibition of the Wnt/beta-catenin signaling. Our results indicated the as-prepared OBX-MMNs hold great potential for MR/PA dual-modal imaging guided mild hyperthermia-enhanced chemotherapy.

引用

页数：10

共 49 条

[1] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[2] Control of Wnt/β-Catenin Signaling Pathway in Vivo via Light Responsive Capsules [J].

Anbrosone, Alfredo ;

Marchesano, Valentina ;

Carregal-Romero, Susana ;

Intartaglia, Daniela ;

Parak, Wolfgang J. ;

Tortiglione, Claudia .

ACS NANO, 2016, 10 (04) :4828-4834

[3]

[Anonymous], CANC RES

[4] Black Phosphorus/Platinum Heterostructure: A Highly Efficient Photocatalyst for Solar-Driven Chemical Reactions [J].

Bai, Licheng ;

Wang, Xin ;

Tang, Shaobin ;

Kang, Yihong ;

Wang, Jiahong ;

Yu, Ying ;

Zhou, Zhang-Kai ;

Ma, Chao ;

Zhang, Xue ;

Jiang, Jun ;

Chu, Paul K. ;

Yu, Xue-Feng .

ADVANCED MATERIALS, 2018, 30 (40)

[5] In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system [J].

Chen, Daiqin ;

Wang, Chao ;

Jiang, Feng ;

Liu, Zhuang ;

Shu, Chunying ;

Wan, Li-Jun .

JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (29) :4726-4732

[6] Cationic poly-L-lysine-encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis [J].

Chen, Liang ;

Ji, Yu ;

Hu, Xiaoming ;

Cui, Cao ;

Liu, Hong ;

Tang, Yufu ;

Qi, Baiwen ;

Niu, Yahui ;

Hu, Xiang ;

Yu, Aixi ;

Fan, Quli .

NANOSCALE, 2018, 10 (28) :13471-13484

[7] An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control [J].

Clevers, Hans ;

Loh, Kyle M. ;

Nusse, Roel .

SCIENCE, 2014, 346 (6205) :54-+

[8] Wnt/β-Catenin Signaling and Disease [J].

Clevers, Hans ;

Nusse, Roel .

CELL, 2012, 149 (06) :1192-1205

[9] Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation [J].

Cui, Liguo ;

Zhang, Jin ;

Zou, Jun ;

Yang, Xianrui ;

Guo, Hui ;

Tian, Huayu ;

Zhang, Peibiao ;

Wang, Yu ;

Zhang, Ning ;

Zhuang, Xiuli ;

Li, Zhongming ;

Ding, Jianxun ;

Chen, Xuesi .

BIOMATERIALS, 2020, 230

[10] A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units [J].

Cui, Peng-Fei ;

Zhuang, Wan-Ru ;

Hu, Xi ;

Xing, Lei ;

Yu, Ru-Yi ;

Qiao, Jian-Bin ;

He, Yu-Jing ;

Li, Fangyuan ;

Ling, Daishun ;

Jiang, Hu-Lin .

CHEMICAL COMMUNICATIONS, 2018, 54 (59) :8218-8221

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