Chemical cross-linking and mass spectrometry for protein structural modeling

被引：188

作者：

Back, JW ^{[1
]}

de Jong, L ^{[1
]}

Muijsers, AO ^{[1
]}

de Koster, CG ^{[1
]}

机构：

[1] Univ Amsterdam, Mass Spectrometry Grp, SILS, NL-1018 WV Amsterdam, Netherlands

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2003年 / 331卷 / 02期

关键词：

cross-linking; mass spectrometry; restraints; protein modeling; integration of techniques;

D O I：

10.1016/S0022-2836(03)00721-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growth of gene and protein sequence information is currently so rapid that three-dimensional structural information is lacking for the overwhelming majority of known proteins. In this review, efforts towards rapid and sensitive methods for protein structural characterization are described, complementing existing technologies. Based on chemical cross-linking and offering the analytical speed and sensitivity of mass spectrometry these methodologies are thought to contribute valuable tools towards future high throughput protein structure elucidation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：303 / 313

页数：11

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