Therapeutic targets and signaling pathways of active components of QiLing decoction against castration-resistant prostate cancer based on network pharmacology

被引:2
作者
Cao, Hongwen [1 ]
Wang, Dan [1 ]
Gao, Renjie [1 ]
Li, Chenggong [2 ]
Feng, Yigeng [1 ]
Chen, Lei [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, LONGHUA Hosp, Urol, Shanghai, Peoples R China
[2] Linshu Hosp Tradit Chinese Med, Androl Urol, Linyi, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
QiLing decoction; Castration-resistant prostate cancer; Network pharmacology; Active components; Signaling pathways; Tumor growth; GROWTH;
D O I
10.7717/peerj.13481
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
QiLing decoction (QLD) is a traditional Chinese medicine compound. This study aims to explore the therapeutic effect of QLD in castration-resistant prostate cancer (CRPC) and its potential bio-targets. A total of 51 active components and QLD 149 targets were identified using bioinformatics analysis. Additionally, five optimal hub target genes were screened including tumor protein P53 (TP53), interleukin-6 (IL-6), vascular endothelial growth factor-A (VEGF-A), caspase-3 (CASP-3), and estrogen receptor-1 (ESR-1). The interrelated network between active components of QLD and their potential targets was constructed. The molecular function, biological processes, and signaling pathways of QLD-against CRPC were identified. Moreover, QLD was found to efficiently exert a repressive effect on CRPC tumor growth mainly by suppressing the activation of HIF-alpha/VEGFA and TNF-alpha/IL6 signaling pathways, and increasing the P53 expression level. These results successfully indicated the potential anti-CRPC mechanism of the active components of QLD.
引用
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页数:20
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