Methotrexate-related Primary Hepatic Lymphoma in a Patient with Rheumatoid Arthritis

被引：17

作者：

Miyagawa, Koichiro ^{[1
]}

Shibata, Michihiko ^{[1
]}

Noguchi, Hirotsugu ^{[2
]}

Hayashi, Tsuguru ^{[1
]}

Oe, Shinji ^{[1
]}

Hiura, Masaaki ^{[1
]}

Abe, Shintaro ^{[1
]}

Harada, Masaru ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Tokyo, Japan

[2] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 04期

关键词：

primary hepatic lymphoma; methotrexate; malignant lymphoma; rheumatoid arthritis; NON-HODGKINS-LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS; LIVER; TOXICITY; INFECTION; EFFICACY; CANCER; RISK;

D O I：

10.2169/internalmedicine.54.3361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 56-year-old woman with rheumatoid arthritis treated with methotrexate (MTX) was admitted to our hospital due to multiple liver tumors. Contrast-enhanced computed tomography (CT) revealed multiple hypovascular masses, and 18F-fluorodeoxyglucose positron emission tomography CT showed diffuse abnormal accumulation in the liver only. We therefore made a diagnosis of MTX-related primary hepatic lymphoma (MTX-PHL) exhibiting features of diffuse large B-cell lymphoma. Although MTX has been reported to increase the risk of lymphoproliferative disorders, MTX-PHL has not been reported previously. The present case is the first case in which MTX appears to have been involved in the development of PHL.

引用

页码：401 / 405

页数：5

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