MECHANISM-BASED INHIBITORS OF GLYCOSIDASES: DESIGN AND APPLICATIONS

被引：28
|
作者：
Kallemeijn, Wouter W. [1 ]
Witte, Martin D. [2 ]
Wennekes, Tom [3 ]
Aerts, Johannes M. F. G. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Groningen, Dept Bioorgan Chem, Stratingh Inst Chem, Groningen, Netherlands
[3] Wageningen Univ, Dept Synthet Organ Chem, NL-6700 AP Wageningen, Netherlands
来源：
ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 71 | 2014年 / 71卷
关键词：
ACID-BETA-GLUCOSIDASE; GLYCOSYL-ENZYME INTERMEDIATE; ACTIVE-SITE NUCLEOPHILE; ACTIVITY-BASED PROBES; GLUCOCEREBROSIDE-CLEAVING ENZYME; LACTASE-PHLORHIZIN HYDROLASE; SUBSTRATE-ASSISTED CATALYSIS; SUCRASE-ISOMALTASE COMPLEX; PROTEIN-PROFILING PROBES; X-RAY CRYSTALLOGRAPHY;
D O I：
10.1016/B978-0-12-800128-8.00004-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：297 / 338
页数：42
相关论文
共 50 条
  • [41] Fluorescent nitrile-based inhibitors of cysteine cathepsins
    Frizler, Maxim
    Mertens, Matthias D.
    Guetschow, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7715 - 7718
  • [42] Conformational analyses of thiirane-based gelatinase inhibitors
    Lee, Mijoon
    Hesek, Dusan
    Shi, Qicun
    Noll, Bruce C.
    Fisher, Jed F.
    Chang, Mayland
    Mobashery, Shahriar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (10) : 3064 - 3067
  • [43] Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors
    Czyzyk, D. J.
    Valhondo, M.
    Deiana, L.
    Tirado-Rives, J.
    Jorgensen, W. L.
    Anderson, K. S.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 183
  • [44] Structural basis for the design of novel Schiff base metal chelate inhibitors of trypsin
    Iyaguchi, Daisuke
    Kawano, Susumu
    Takada, Kazuki
    Toyota, Eiko
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (06) : 2076 - 2080
  • [45] Beyond Heparinization: Design of Highly Potent Thrombin Inhibitors Suitable for Surface Coupling
    Steinmetzer, Torsten
    Baum, Bernhard
    Biela, Adam
    Klebe, Gerhard
    Nowak, Goetz
    Bucha, Elke
    CHEMMEDCHEM, 2012, 7 (11) : 1965 - 1973
  • [46] N-Hydroxyurea -: A versatile zinc binding function in the design of metalloenzyme inhibitors
    Temperini, Claudia
    Innocenti, Alessio
    Scozzafava, Andrea
    Supuran, Claudiu T.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (16) : 4316 - 4320
  • [47] Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities
    Novakova, Zora
    Cerny, Jiri
    Choy, Cindy J.
    Nedrow, Jessie R.
    Choi, Joeseph K.
    Lubkowski, Jacek
    Berkman, Clifford E.
    Barinka, Cyril
    FEBS JOURNAL, 2016, 283 (01) : 130 - 143
  • [48] The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition
    Pakhomova, S
    Buck, J
    Newcomer, ME
    PROTEIN SCIENCE, 2005, 14 (01) : 176 - 182
  • [49] Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation of Novel Sulfonyl Sennicarbazide Derivatives
    Pichake, Jayashree
    Kharkar, Prashant S.
    Ceruso, Mariangela
    Supuran, Claudiu T.
    Toraskar, Mrunmayee P.
    ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (07): : 793 - 796
  • [50] Structure-based drug discovery of carbonic anhydrase inhibitors
    Supuran, Claudiu T.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012, 27 (06) : 759 - 772
12345