Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis

被引：36

作者：

Edwards, Alexander ^{[1
]}

Gao, Yifang ^{[2
,3
]}

Allan, Raymond N. ^{[1
,4
]}

Ball, Darran ^{[4
]}

de Graaf, Hans ^{[1
,4
,5
]}

Coelho, Tracy ^{[1
,6
]}

Clifford, Vanessa ^{[7
,8
]}

Curtis, Nigel ^{[7
,8
]}

Williams, Anthony ^{[2
,3
,9
,10
]}

Faust, Saul N. ^{[1
,4
,11
,12
]}

Mansour, Salah ^{[1
]}

Marshall, Ben ^{[1
,11
,13
]}

Elkington, Paul ^{[1
,11
,13
]}

Tebruegge, Marc ^{[1
,7
,8
,11
,12
]}

机构：

[1] Univ Southampton, Fac Med, Acad Unit Clin & Expt Sci, Southampton, Hants, England

[2] Univ Southampton, Acad Unit Canc Sci, Fac Med, Southampton, Hants, England

[3] Univ Hosp Southampton NHS Fdn Trust, CRUK NIHR Southampton Expt Canc Med Ctr, Southampton, Hants, England

[4] Univ Hosp Southampton NHS Fdn Trust, NIHR Wellcome Trust Clin Res Facil, Mailpoint 218,Tremona Rd, Southampton SO16 6YD, Hants, England

[5] Univ Hosp Southampton NHS Fdn Trust, Dept Paediat Rheumatol, Southampton, Hants, England

[6] Univ Hosp Southampton NHS Fdn Trust, Dept Paediat Gastroenterol, Southampton, Hants, England

[7] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia

[8] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[9] Univ Hosp Southampton NHS Fdn Trust, Dept Immunol, Southampton, Hants, England

[10] Univ Hosp Southampton NHS Fdn Trust, Wessex Invest Sci Hub, Southampton, Hants, England

[11] Univ Hosp Southampton NHS Fdn Trust, NIHR Resp Biomed Res Unit, Southampton, Hants, England

[12] Univ Hosp Southampton NHS Fdn Trust, Dept Paediat Infect Dis & Immunol, Southampton, Hants, England

[13] Univ Hosp NHS Fdn Trust, Dept Resp Med, Southampton, Hants, England

来源：

THORAX | 2017年 / 72卷 / 10期

基金：

英国惠康基金;

关键词：

QUANTIFERON-TB GOLD; MYCOBACTERIUM-TUBERCULOSIS; RHEUMATOID-ARTHRITIS; CYTOKINE PRODUCTION; BIOLOGICAL THERAPY; SCREENING-TESTS; ALPHA THERAPY; TUBE ASSAYS; INFECTION; SERUM;

D O I：

10.1136/thoraxjnl-2016-209397

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The impact of immunosuppression on interferon-gamma release assays and novel cytokine biomarkers of TB infection, mycobacteria-specific IL-2, IP-10 and TNF-alpha responses was investigated in an ex vivo model. Cytokine responses in standard QuantiFERON-TB Gold in-Tube (QFT-GIT) assays were compared with duplicate assays containing dexamethasone or infliximab. Dexamethasone converted QFT-GIT results from positive to negative in 30% of participants. Antigen-stimulated interferon-gamma, IL-2 and TNF-alpha responses were markedly reduced, but IP-10 responses were preserved. Infliximab caused QFT-GIT result conversion in up to 30% of participants and substantial reductions in all cytokine responses. Therefore, corticosteroids and anti-TNF-alpha agents significantly impair interferon-gamma release assay performance. IP-10 may be a more robust TB biomarker than interferon-gamma in patients receiving corticosteroids.

引用

页码：946 / 949

页数：4

共 22 条

[1] Prednisolone Treatment Affects the Performance of the QuantiFERON Gold In-Tube Test and the Tuberculin Skin Test in Patients with Autoimmune Disorders Screened for Latent Tuberculosis Infection
Belard, Erika
Semb, Synne
Ruhwald, Morten
Werlinrud, Anne Marie
Soborg, Bolette
Jensen, Frank Krieger
Thomsen, Henrik
Brylov, Annette
Hetland, Merete Lund
Nordgaard-Lassen, Inge
Ravn, Pernille
[J]. INFLAMMATORY BOWEL DISEASES, 2011, 17 (11) : 2340 - 2349
[2] BRINKMANN V, 1995, J IMMUNOL, V155, P3322
[3] Diagnosis of tuberculosis infection by tuberculin skin test and a whole-blood interferon-γ release assay in patients considered for anti-tumor necrosis factor-α therapy
Casas, Susana
Andreu, Ana
Juanola, Xavier
Bordas, Xavier
Alcaide, Fernando
Moure, Raquel
Anibarro, Luis
Cuchi, Eva
Esteve, Maria
Ortiz, Vera
Rosario Guerra, Maria
Rodriguez, Jesus
Reina, Delia
Salvador, Georgina
Guardiola, Jordi
Suris, Xavier
Angeles Pascual, Maria
Marti, Carmina
Martinez-Lacasa, Xavier
Cuquet, Jordi
Gonzalez, Lucia
Santin, Miguel
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2011, 71 (01) : 57 - 65
[4] Interferon-Gamma Release Assays for the Diagnosis of Latent Tuberculosis Infection in HIV-Infected Individuals: A Systematic Review and Meta-Analysis
Cattamanchi, Adithya
Smith, Rachel
Steingart, Karen R.
Metcalfe, John Z.
Date, Anand
Coleman, Courtney
Marston, Barbara J.
Huang, Laurence
Hopewell, Philip C.
Pai, Madhukar
[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 56 (03) : 230 - 238
[5] Cellestis/ Qiagen, 2013, QuantiFERON- TB Gold Package Insert (Doc. No. US05990301L, Version, Patent No. 05990301
[6] The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis - Results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial
Clair, EWS
Wagner, CL
Fasanmade, AA
Wang, B
Schaible, T
Kavanaugh, A
Keystone, EC
[J]. ARTHRITIS AND RHEUMATISM, 2002, 46 (06): : 1451 - 1459
[7] The impact of anti-tuberculous antibiotics and corticosteroids on cytokine production in QuantiFERON-TB Gold In Tube assays
Clifford, Vanessa
Zufferey, Christel
Germano, Susie
Ryan, Norbert
Leslie, David
Street, Alan
Denholm, Justin
Tebruegge, Marc
Curtis, Nigel
[J]. TUBERCULOSIS, 2015, 95 (03) : 343 - 349
[8] SCREENING TESTS FOR TB BEFORE BIOLOGICAL THERAPY Limitations of current tuberculosis screening tests in immunosuppressed patients
Clifford, Vanessa
Tebruegge, Marc
Curtis, Nigel
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2015, 350
[9] Development of a human gamma interferon enzyme immunoassay and comparison with tuberculin skin testing for detection of Mycobacterium tuberculosis infection
Desem, N
Jones, SL
[J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1998, 5 (04) : 531 - 536
[10] Yield and cost effectiveness of mycobacterial infection detection using a simple IGRA-based protocol in UK subjects with inflammatory bowel disease suitable for anti-TNFα therapy
Greveson, Kay
Goodhand, James
Capocci, Santino
Woodward, Sue
Murray, Charles
Cropley, Ian
Hamilton, Mark
Lipman, Marc
[J]. JOURNAL OF CROHNS & COLITIS, 2013, 7 (05) : 412 - 418

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