HIV-1;
tat;
oligoarginine;
penetratin;
cell permeable peptide;
protein transduction;
drug delivery;
D O I:
10.1016/j.addr.2004.10.009
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The intracellular delivery of proteins and other bioactive molecules using membrane-permeable carrier peptide vectors opens the possibility of establishing novel methods of elucidating and controlling cell functions with therapeutic potentials. One of the most typical peptide vectors is a short, arginine-rich peptide segment derived from the human immunodeficiency virus (HIV)-1 Tat protein. We have shown that not only the Tat peptide, but also various arginine-rich oligopeptides possess very similar characteristics in translocation and abilities as a delivery vector. This review summarizes the structures of these peptide vectors, especially the Tat and other arginine-rich peptides, and the current understanding of their internalization mechanisms. (c) 2004 Elsevier B.V All rights reserved.