In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts

被引：41
|
作者：
Akkoc, Senem [1 ,2 ]
Ilhan, Ilhan Ozer [2 ]
Gok, Yetkin [3 ]
Upadhyay, Parth J. [1 ]
Kayser, Veysel [1 ]
机构：
[1] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia
[2] Erciyes Univ, Fac Sci, Dept Chem, Talas St, TR-38039 Kayseri, Turkey
[3] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44280 Malatya, Turkey
来源：
INORGANICA CHIMICA ACTA | 2016年 / 449卷
关键词：
N-heterocyclic carbene complexes; Benzimidazolium salts; Cytotoxic activity; DLD-1; MDA-MB-231; HEK-293T; ANTICANCER ACTIVITY; CATALYTIC-ACTIVITY; NANOPARTICLES;
D O I：
10.1016/j.ica.2016.05.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
New benzimidazolium salts (2, 3) and their silver (4, 5) and palladium (6, 7) N-heterocyclic carbene (Ag-and Pd-NHC) complexes were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and UV-Vis spectroscopic methods. All the synthesized compounds were tested in human colon cancer (DLD-1), breast cancer (MDA-MB-231) and embryonic kidney (HEK 293T) (non-cancerous) cell lines for in vitro cytotoxicity. Compound 4 specifically showed low IC50 values for these cell lines (IC50 values 12.41 +/- 2.89, 11.98 +/- 2.52 and 4.21 +/- 1.74 mu mol/L in DLD-1, MDA-MB-231 and HEK 293T cell lines, respectively). The Pd-NHC complexes (6, 7) did not exhibit cytotoxic activity (IC50 values > 200 in DLD-1, MDA-MB-231, HEK 293T cell lines). Therefore, Ag-NHC complexes can be further investigated as potential anticancer agents. (C) 2016 Elsevier B. V. All rights reserved.
引用
收藏
页码：75 / 81
页数：7
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