In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts

被引：41
|
作者：
Akkoc, Senem [1 ,2 ]
Ilhan, Ilhan Ozer [2 ]
Gok, Yetkin [3 ]
Upadhyay, Parth J. [1 ]
Kayser, Veysel [1 ]
机构：
[1] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia
[2] Erciyes Univ, Fac Sci, Dept Chem, Talas St, TR-38039 Kayseri, Turkey
[3] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44280 Malatya, Turkey
来源：
INORGANICA CHIMICA ACTA | 2016年 / 449卷
关键词：
N-heterocyclic carbene complexes; Benzimidazolium salts; Cytotoxic activity; DLD-1; MDA-MB-231; HEK-293T; ANTICANCER ACTIVITY; CATALYTIC-ACTIVITY; NANOPARTICLES;
D O I：
10.1016/j.ica.2016.05.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
New benzimidazolium salts (2, 3) and their silver (4, 5) and palladium (6, 7) N-heterocyclic carbene (Ag-and Pd-NHC) complexes were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and UV-Vis spectroscopic methods. All the synthesized compounds were tested in human colon cancer (DLD-1), breast cancer (MDA-MB-231) and embryonic kidney (HEK 293T) (non-cancerous) cell lines for in vitro cytotoxicity. Compound 4 specifically showed low IC50 values for these cell lines (IC50 values 12.41 +/- 2.89, 11.98 +/- 2.52 and 4.21 +/- 1.74 mu mol/L in DLD-1, MDA-MB-231 and HEK 293T cell lines, respectively). The Pd-NHC complexes (6, 7) did not exhibit cytotoxic activity (IC50 values > 200 in DLD-1, MDA-MB-231, HEK 293T cell lines). Therefore, Ag-NHC complexes can be further investigated as potential anticancer agents. (C) 2016 Elsevier B. V. All rights reserved.
引用
收藏
页码：75 / 81
页数：7
相关论文
共 50 条
  • [21] Platinum(IV) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity
    Bouche, M.
    Dahm, G.
    Wantz, M.
    Fournel, S.
    Achard, T.
    Bellemin-Laponnaz, S.
    DALTON TRANSACTIONS, 2016, 45 (28) : 11362 - 11368
  • [22] Cytotoxic properties of rhenium(i) tricarbonyl complexes of N-heterocyclic carbene ligands
    Wiratpruk, Nuchareenat
    Bindra, Guneet K.
    Hamilton, Alex
    Hulett, Mark D.
    Barnard, Peter J.
    DALTON TRANSACTIONS, 2022, 51 (19) : 7630 - 7643
  • [23] Synthesis and structural characterization of N-heterocyclic carbene silver complexes derived from N-ferrocenylmethyl-N′-(pyridylmethyl)imidazolium iodides
    Li, Qiang
    Li, Xin
    Yang, Jun
    Song, Hai-Bin
    Tang, Liang-Fu
    POLYHEDRON, 2013, 59 : 29 - 37
  • [24] In situ Generation of Efficient Palladium N-heterocyclic Carbene Catalysts Using Benzimidazolium Salts for the Suzuki-Miyaura Cross-coupling Reaction
    Akkoc, Senem
    Gok, Yetkin
    Ilhan, Ilhan Ozer
    Kayser, Veysel
    CURRENT ORGANIC SYNTHESIS, 2016, 13 (05) : 761 - 766
  • [25] In vitro antimicrobial studies of naphthalen-1-ylmethyl substituted silver N-heterocyclic carbene complexes
    Gok, Yetkin
    Akkoc, Senem
    Celikal, Ozlem Ozeroglu
    Ozdemir, Ilknur
    Gunal, Selami
    ARABIAN JOURNAL OF CHEMISTRY, 2019, 12 (08) : 2513 - 2518
  • [26] Palladium N-heterocyclic carbene complexes for the Mizoroki-Heck reaction: An appraisal
    Balinge, Kamlesh Rudreshwar
    Bhagat, Pundlik Rambhau
    COMPTES RENDUS CHIMIE, 2017, 20 (07) : 773 - 804
  • [27] Experimental and quantum mechanical investigation on two N-heterocyclic carbene palladium complexes
    Ozdemir, Namik
    Touj, Nedra
    Yasar, Sedat
    Hamdi, Naceur
    Ozdemir, Ismail
    MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2021, 714 (01) : 26 - 36
  • [28] Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities
    Zhang, Jing-Jing
    Che, Chi-Ming
    Ott, Ingo
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 782 : 37 - 41
  • [29] Synthesis, Structural Analysis and Antimicrobial Activities of Novel Water Soluble Ionic Liquids Derived from N-Heterocyclic Carbene Salts
    Kunduracioglu, Ahmet
    Gube, Ozkan
    Hames-Kocabas, Elif Esin
    Eyupoglu, Volkan
    Sonmez, Fatih
    CROATICA CHEMICA ACTA, 2016, 89 (01) : 105 - 110
  • [30] Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy
    Holmes, Jordan
    Kearsey, Rachel J.
    Paske, Katie A.
    Singer, Frances N.
    Atallah, Suliman
    Pask, Christopher M.
    Phillips, Roger M.
    Willans, Charlotte E.
    ORGANOMETALLICS, 2019, 38 (12) : 2530 - 2538
12345