A Life in Bacillus subtilis Signal Transduction

被引：16

作者：

Hoch, James A. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 71 | 2017年 / 71卷

基金：

美国国家卫生研究院;

关键词：

sporulation; phosphorelay; two-component signaling; signal protein structures; protein interaction; TRANSITION-STATE REGULATOR; SENSOR HISTIDINE KINASE; SPORULATION TRANSCRIPTION FACTOR; YYCFG 2-COMPONENT SYSTEM; ASPARTYL-PHOSPHATE PHOSPHATASES; GENE-ENZYME RELATIONSHIPS; DIRECT RESIDUE CONTACTS; DNA-BINDING PROTEIN; RESPONSE-REGULATOR; MOLECULAR RECOGNITION;

D O I：

10.1146/annurev-micro-030117-020355

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins evolve interaction specificity and to identification of interaction surfaces by statistical physics. This is about how the people in my laboratory accomplished this feat; without them little would have been done.

引用

页码：1 / 19

页数：19

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