Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia

被引：17
作者：
Kulinskii, VI [1 ]
Mikhel'son, GV [1 ]
机构：
[1] Irkutsk Med Univ, Dept Biochem, Irkutsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 130卷 / 08期
基金：
俄罗斯基础研究基金会;
关键词：
cerebral ischemia; neuroprotectors; GABA receptors; additivity of agonist effects;
D O I：
10.1007/BF02766091
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABA(A) and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA(A) and GABA(B) antagonists separately and in combination is not below the estimated value. Therefore, GABA(A) and GABA(B) receptor mechanisms of the neuroprotective effects independently and separately contribute to the improvement of brain resistance to global ischemia.
引用
收藏
页码：772 / 774
页数：3
相关论文
共 13 条
[1]  
ALEXANDER SPH, 1998, TRENDS PHARM S, V33, P33
[2]  
BOWERY NG, 1999, NEUROTRANSMISSION, V18, P3
[3]  
BOWERY NG, 1999, NEUROTRANSMISSION, V15, P18
[4]  
Enna S. J., 1997, GABA RECEPTORS
[5]   Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors [J].
Ito, H ;
Watanabe, Y ;
Isshiki, A ;
Uchino, H .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1999, 43 (02) :153-162
[6]   High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: A quantal bioassay study using the intraluminal suture occlusion method [J].
JacksonFriedman, C ;
Lyden, PD ;
Nunez, S ;
Jin, A ;
Zweifler, R .
EXPERIMENTAL NEUROLOGY, 1997, 147 (02) :346-352
[7]  
Kulinskii V. I., 1997, Eksperimental'naya i Klinicheskaya Farmakologiya, V60, P56
[8]  
Kulinskii V. I., 1993, Eksperimental'naya i Klinicheskaya Farmakologiya, V56, P13
[9]   Effect of bilateral destruction of the subretrofacial area on receptor mechanisms of neuroprotective effect of GABAergic agents [J].
Kulinskii, VI ;
Mickhel'son, GV .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1998, 125 (02) :139-141
[10]  
KULINSKII VI, 1996, NEIROKHIMIYA, V13, P56
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