The wolframin His611Arg polymorphism influences medication overuse headache

被引：30

作者：

Di Lorenzo, C. ^{[1
]}

Sances, G.

Di Lorenzo, G.

Rengo, C.

Ghiotto, N.

Guaschino, E.

Perrotta, A.

Santorelli, F. M.

Grieco, G. S.

Troisi, A.

Siracusano, A.

Pierelli, F.

Nappi, G.

Casali, C.

机构：

[1] Univ La Sapienza, UCADH, Dept Neurol & ORL, Latina, Italy

[2] IRCCS, C Mondino Inst Neurol Fdn, UCADH, Headache Unit, Pavia, Italy

[3] Univ Roma Tor Vergata, Dept Neurosci, Psychiat Clin, Rome, Italy

[4] IRCCS San Raffaele, C Mondino Inst Neurol Fdn, Mol Genet Lab, Rome, Italy

[5] IRCCS Bambino Gesu, Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2007年 / 424卷 / 03期

关键词：

wolframin; genetic polymorphisms; secondary headache disorder; drug overuse; addictive behaviour;

D O I：

10.1016/j.neulet.2007.07.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homozygosis for wolframin (WFS1) mutations determines Wolfram syndrome (WS), and common polymorphisms of WFS1 are associated with psychiatric illnesses and dependence behaviour. To test the influence of WFS1 polymorphisms on medication overuse headache (MOH), a chronic headache condition related to symptomatic drugs overuse, we analyzed 82 MOH patients for the WFS1 His61 lArg polymorphism, and performed a comparison between clinical features of Arg/Arg (R/R) and non-R/R individuals. Individuals harbouring the R/R genotype showed significantly higher monthly drug consumption (t= -3.504; p =0.00075) and more severe depressive symptoms on the BDI questionnaire -3.048; p = 0.003) than non-R/R. WFS1 polymorphism emerged as the only significant predictor of drug consumption, at the multivariate, regression analysis (F = 12.277; d.f. = 1,80; p = 0.00075, adjusted R-2 = 0.122). These results implicate WFS1 in the clinical picture of MOH, may be through an influence on need for drugs as in other conditions of abuse behaviour. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：179 / 184

页数：6

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