The Metabolic Syndrome Predicts Longitudinal Changes in Clock Drawing Test Performance in Older Nondemented Hypertensive Individuals

被引：17

作者：

Viscogliosi, Giovanni ^{[1
,2
]}

Chiriac, Iulia Maria ^{[3
]}

Andreozzi, Paola ^{[1
]}

Ettorre, Evaristo ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Div Gerontol, Rome, Italy

[2] Natl Inst Hlth, Dept Epidemiol Surveillance & Promot Hlth, Rome, Italy

[3] Casa Cura Merry House, Div Geriatr, Rome, Italy

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2016年 / 24卷 / 05期

关键词：

cognitive decline; clock drawing test; metabolic syndrome; DEMENTIA; RISK;

D O I：

10.1016/j.jagp.2015.09.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: The present study evaluated the metabolic syndrome (MetS) as independent predictor of 1-year longitudinal changes in cognitive function. Methods: 104 stroke-and dementia-free older hypertensive subjects were studied. MetS was defined by NCEP ATP-III criteria. Cognitive function was assessed by the Clock Drawing Test (CDT); 1-year changes in cognitive function were expressed as annual changes in CDT performance. Brain magnetic resonance imaging studies (1.5T) were performed. Results: Participants with MetS exhibited greater cognitive decline than those without (-1.78 +/- 1.47 versus -0.74 +/- 1.44 CDT points, t = 3.348, df = 102, p < 0.001). MetS predicted cognitive decline (beta = -0.327, t = -3.059, df = 96, p = 0.003) independently of its components, age, baseline cognition, neuroimaging findings, blood pressure levels, and duration of hypertension. With the exception of systolic blood pressure, none of the individual components of MetS explained 1-year changes in CDT performance. Conclusions: MetS as an entity predicted accelerated 1-year decline in cognitive function, assessed by CDT, in a sample of older hypertensive subjects.

引用

页码：359 / 363

页数：5

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