Vestibular and cochlear toxicity of aminoglycosides - A review

被引:72
作者
Nakashima, T
Teranishi, M
Hibi, T
Kobayashi, M
Umemura, M
机构
[1] Nagoya Univ, Sch Med, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Nagoya Univ, Sch Med, Dept Hosp Pharm, Showa Ku, Nagoya, Aichi 4668550, Japan
关键词
aminoglycosides; cochleotoxicity; Meniere's disease; intratympanic administration; vestibulotoxicity;
D O I
10.1080/00016480050218627
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Recently, there have been many reports describing the efficacy of intratympanic aminoglycoside injection for the treatment of intractable vertigo in patients with Meniere's disease. However, the number of injections and the amount of drug injected varies, with concomitant variation in the aide-effect of hearing deterioration. To identify drugs that are more selectively vestibulotoxic. ae have reviewed the ototoxicity of aminoglycosides, focusing on differences between vestibulo- and cochleotoxicity. At present, the basis for the different effects of each drug is unknown. The mechanisms of vestibulo- and cochleotoxicity are deemed worthy of further study.
引用
收藏
页码:904 / 911
页数:8
相关论文
共 83 条
[1]  
AKIYOSHI M, 1985, AMINOGLYCOSIDE, P123
[2]   INTERACTION OF AMINOGLYCOSIDE ANTIBIOTICS WITH PHOSPHOLIPID LIPOSOMES STUDIES BY MICRO-ELECTROPHORESIS [J].
ALEXANDER, AM ;
GONDA, I ;
HARPUR, ES ;
KAYES, JB .
JOURNAL OF ANTIBIOTICS, 1979, 32 (05) :504-510
[3]   ASPECTS ON THE OTOTOXIC POTENTIAL OF NETILMICIN [J].
ANNIKO, M .
ACTA OTO-LARYNGOLOGICA, 1983, 96 (1-2) :75-89
[4]   THE COMPARATIVE OTOTOXICITIES OF GENTAMICIN, TOBRAMYCIN AND DIBEKACIN IN THE GUINEA-PIG, A FUNCTIONAL AND MORPHOLOGICAL COCHLEAR AND VESTIBULAR STUDY [J].
ARAN, JM ;
ERRE, JP ;
GUILHAUME, A ;
AUROUSSEAU, C .
ACTA OTO-LARYNGOLOGICA, 1982, :1-30
[5]   UPTAKE OF AMIKACIN BY HAIR-CELLS OF THE GUINEA-PIG COCHLEA AND VESTIBULE AND OTOTOXICITY - COMPARISON WITH GENTAMICIN [J].
ARAN, JM ;
CHAPPERT, C ;
DULON, D ;
ERRE, JP ;
AUROUSSEAU, C .
HEARING RESEARCH, 1995, 82 (02) :179-183
[6]  
BAGGERSJOBACK D, 1990, AM J OTOL, V11, P406
[7]  
BAMONTE F, 1988, Journal of Drug Development, V1, P97
[8]   10 YEARS OF EXPERIENCE WITH INTRATYMPANALLY APPLIED STREPTOMYCIN (GENTAMICIN) IN THERAPY OF MORBUS MENIERE [J].
BECK, C ;
SCHMIDT, CL .
ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE-ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1978, 221 (02) :149-152
[9]   Update on intratympanic gentamicin for Meniere's disease [J].
Blakley, BW .
LARYNGOSCOPE, 2000, 110 (02) :236-240
[10]   EFFECTS OF N-ACETYLCYSTEINE ON KANAMYCIN OTOTOXICITY IN THE GUINEA-PIG [J].
BOCK, GR ;
YATES, GK ;
MILLER, JJ ;
MOORJANI, P .
HEARING RESEARCH, 1983, 9 (03) :255-262