Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: New approaches to old problems

被引:153
作者
Parsons, J. Kellogg [1 ]
机构
[1] Univ Calif San Diego, Div Urol, Sch Med, San Diego, CA 92103 USA
关键词
prostate; prostatic hyperplasia; risk factors; epidemiology; urination disorders;
D O I
10.1016/j.juro.2007.03.103
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Benign prostatic hyperplasia is generally not regarded as a preventable disease. However, accumulating evidence suggests that modifiable factors may influence the risk of benign prostatic hyperplasia and lower urinary tract symptoms. Materials and Methods: A structured, comprehensive literature review was done to identify modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms among observational studies of older men. Results: Outcome measures used to define benign prostatic hyperplasia in clinical studies include histological analysis of prostate tissue, radiographically determined prostate enlargement, acute urinary retention, decreased urinary flow rate, pressure flow studies consistent with bladder outlet obstruction, history of benign prostatic hyperplasia surgery, physician diagnosed benign prostatic hyperplasia and American Urological Association symptom score or International Prostate Symptom Score. Factors that potentially increase the risk of benign prostatic hyperplasia and lower urinary tract symptoms include obesity and diabetes. Factors that potentially decrease the risk include increased physical activity and moderate alcohol consumption. Other candidate factors for which clear risk patterns have not yet emerged are dyslipidemia, hypertension, smoking, diet and environment. Conclusions: Obesity, diabetes, physical activity and alcohol intake may substantially influence the risk of benign prostatic hyperplasia and lower urinary tract symptoms in older men. Further analyses of these and other potential modifiable risk factors may identify novel interventions for the prevention, diagnosis and treatment of these highly prevalent conditions.
引用
收藏
页码:395 / 401
页数:7
相关论文
共 50 条
[1]   Macronutrients, fatty acids, cholesterol, and risk of benign prostatic hyperplasia [J].
Bravi, F ;
Bosetti, C ;
Dal Maso, L ;
Talamini, R ;
Montella, M ;
Negri, E ;
Ramazzotti, V ;
Franceschi, S ;
La Vecchia, C .
UROLOGY, 2006, 67 (06) :1205-1211
[2]   Food groups and risk of benign prostatic hyperplasia [J].
Bravi, F ;
Bosetti, C ;
Dal Maso, L ;
Talamini, R ;
Montella, M ;
Negri, E ;
Ramazzotti, V ;
Franceschi, S ;
La Vecchia, C .
UROLOGY, 2006, 67 (01) :73-79
[3]   Association of anthropometric measures with the presence and progression of benign prostatic hyperplasia [J].
Burke, James P. ;
Rhodes, Thomas ;
Jacobson, Debra J. ;
McGree, Michaela E. ;
Roberts, Rosebud O. ;
Girman, Cynthia J. ;
Lieber, Michael M. ;
Jacobsen, Steven J. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 164 (01) :41-46
[4]   Insulin-like growth factors and risk of benign prostatic hyperplasia [J].
Chokkalingam, AP ;
Gao, YT ;
Deng, J ;
Stanczyk, FZ ;
Sesterhenn, IA ;
Mostofi, FK ;
Fraumeni, JF ;
Hsing, AW .
PROSTATE, 2002, 52 (02) :98-105
[5]   A PROSPECTIVE-STUDY OF ALCOHOL, DIET, AND OTHER LIFE-STYLE FACTORS IN RELATION TO OBSTRUCTIVE UROPATHY [J].
CHYOU, PH ;
NOMURA, AMY ;
STEMMERMANN, GN ;
HANKIN, JH .
PROSTATE, 1993, 22 (03) :253-264
[6]   Alcohol and the risk of prostate cancer and benign prostatic hyperplasia [J].
Crispo, A ;
Talamini, R ;
Gallus, S ;
Negri, E ;
Gallo, A ;
Bosetti, C ;
La Vecchia, C ;
Dal Maso, L ;
Montella, M .
UROLOGY, 2004, 64 (04) :717-722
[7]   Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia [J].
Dahle, SE ;
Chokkalingam, AP ;
Gao, YT ;
Deng, J ;
Stanczyk, FZ ;
Hsing, AW .
JOURNAL OF UROLOGY, 2002, 168 (02) :599-604
[8]   Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia [J].
Dal Maso, L ;
Zucchetto, A ;
Tavani, A ;
Montella, M ;
Ramazzotti, V ;
Polesel, J ;
Bravi, F ;
Talamini, R ;
La Vecchia, C ;
Franceschi, S .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (10) :2632-2635
[9]   Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: A retrospective analysis [J].
Di Silverio, F ;
Gentile, V ;
De Matteis, A ;
Mariotti, G ;
Giuseppe, V ;
Luigi, PA ;
Sciarra, A .
EUROPEAN UROLOGY, 2003, 43 (02) :164-175
[10]   Increased oxidative stress in obesity and its impact on metabolic syndrome [J].
Furukawa, S ;
Fujita, T ;
Shimabukuro, M ;
Iwaki, M ;
Yamada, Y ;
Nakajima, Y ;
Nakayama, O ;
Makishima, M ;
Matsuda, M ;
Shimomura, I .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (12) :1752-1761