Animal models of vertical bone augmentation (Review)

被引：16

作者：

Zhang, Zepeng ^{[1
]}

Gan, Yaxin ^{[1
]}

Guo, Yarong ^{[1
]}

Lu, Xuguang ^{[1
]}

Li, Xianqi ^{[1
,2
]}

机构：

[1] Shanxi Med Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Taiyuan 030001, Shanxi, Peoples R China

[2] Matsumoto Dent Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 1780 Gobara Hirooka, Shiojiri, Nagano 3990781, Japan

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2021年 / 22卷 / 03期

关键词：

animal models; vertical bone augmentation; bone ring technique; guided bone regeneration; biomaterials; preclinical experiment; 2-STAGED IMPLANT PLACEMENT; DEFICIENT ALVEOLAR RIDGES; MESENCHYMAL STEM-CELLS; MORPHOGENETIC PROTEIN-2; RING TECHNIQUE; IN-VIVO; PERIOSTEAL DISTRACTION; CALCIUM-PHOSPHATE; CARTILAGE REPAIR; REGENERATION;

D O I：

10.3892/etm.2021.10351

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Vertical bone augmentation is an important challenge in dental implantology. Existing vertical bone augmentation techniques, along with bone grafting materials, have achieved certain clinical progress but continue to have numerous limitations. In order to evaluate the possibility of using biomaterials to develop bone substitutes, medical devices and/or new bone grafting techniques for vertical bone augmentation, it is essential to establish clinically relevant animal models to investigate their biocompatibility, mechanical properties, applicability and safety. The present review discusses recent animal experiments related to vertical bone augmentation. In addition, surgical protocols for establishing relevant preclinical models with various animal species were reviewed. The present study aims to provide guidance for selecting experimental animal models of vertical bone augmentation.

引用

页数：13

共 100 条

[1] Interspecies differences in bone composition, density, and quality:: Potential implications for in vivo bone research [J].