Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

被引：116

作者：

Strop, Pavel ^{[1
]}

Delaria, Kathy ^{[1
]}

Foletti, Davide ^{[1
]}

Witt, Jody Melton ^{[1
]}

Hasa-Moreno, Adela ^{[1
]}

Poulsen, Kris ^{[1
]}

Casas, Meritxell Galindo ^{[1
]}

Dorywalska, Magdalena ^{[1
]}

Farias, Santiago ^{[1
]}

Pios, Ariel ^{[1
]}

Lui, Victor ^{[1
]}

Dushin, Russell ^{[2
]}

Zhou, Dahui ^{[2
]}

Navaratnain, Thayalan ^{[2
]}

Trani, Thomas-Toan ^{[1
]}

Sutton, Janette ^{[1
]}

Lindquist, Kevin C. ^{[1
]}

Han, Bora ^{[3
]}

Litt, Shu-Hui ^{[1
]}

Shelton, David L. ^{[1
]}

Pons, Jaume ^{[1
]}

Rajpal, Arvind ^{[1
]}

机构：

[1] Pfizer Inc, Rinat Labs, San Francisco, CA 94080 USA

[2] Pfizer Inc, Worldwide Med Chem, Groton, CT 06340 USA

[3] Pfizer Inc, Drug Safety Res & Dev, San Diego, CA USA

来源：

NATURE BIOTECHNOLOGY | 2015年 / 33卷 / 07期

关键词：

STABILITY;

D O I：

10.1038/nbt.3274

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：694 / 696

页数：3

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