A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents

被引：76

作者：

Forte, Andreia ^{[1
]}

Melo, Catarina I. ^{[1
]}

Bogel-Lukasik, Rafal ^{[2
]}

Bogel-Lukasik, Ewa ^{[1
]}

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, Portugal

[2] IP, Unit Bioenergy, Lab Nacl Energia & Geol, P-1649038 Lisbon, Portugal

来源：

FLUID PHASE EQUILIBRIA | 2012年 / 318卷

关键词：

Isoniazid; Ionic liquid; Solubility; Solid-liquid equilibria; Thermochemical properties; Drug; Antibiotic; TEMPERATURE IONIC LIQUIDS; SUPERCRITICAL CARBON-DIOXIDE; PHASE-EQUILIBRIUM PHENOMENA; FUNCTIONALIZED SIDE-CHAINS; DIFFERENT HEAD GROUPS; PHYSICOCHEMICAL PROPERTIES; FREE-ENERGY; MIXTURES; ALCOHOLS; 1-HEXYL-3-METHYLIMIDAZOLIUM;

D O I：

10.1016/j.fluid.2012.01.022

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid-liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid-liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：89 / 95

页数：7

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