Evaluation of an Integrated Device Diagnostics Algorithm to Risk Stratify Heart Failure Patients - Results From the SCAN-HF Study -

被引：5

作者：

Okumura, Ken ^{[1
,2
]}

Sasaki, Shingo ^{[2
]}

Kusano, Kengo ^{[3
]}

Mine, Takanao ^{[4
]}

Fujii, Kenshi ^{[5
]}

Iwasa, Atsushi ^{[6
]}

Sunagawa, Osahiko ^{[7
]}

Yamabe, Hiroshige ^{[8
]}

Takahashi, Naohiko ^{[9
]}

Ishii, Shunsuke ^{[10
]}

Takeishi, Yasuchika ^{[11
]}

Tsuboi, Naoya ^{[12
]}

Shizuta, Satoshi ^{[13
]}

Aonuma, Kazutaka ^{[14
]}

Shimane, Akira ^{[15
]}

Tada, Hiroshi ^{[16
]}

Ishikawa, Toshiyuki ^{[17
]}

Tsunoda, Ryusuke ^{[18
]}

Numata, Tetsuya ^{[19
]}

Mukai, Yasushi ^{[20
]}

Kihara, Yasuki ^{[21
]}

Koehler, Jodi ^{[22
]}

Hidaka, Kazuhiro ^{[23
]}

Sharma, Vinod ^{[22
]}

机构：

[1] Saiseikai Kumamoto Hosp, Div Cardiol, Kumamoto, Japan

[2] Hirosaki Univ, Dept Cardiol, Grad Sch Med, Hirosaki, Aomori, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, Suita, Osaka, Japan

[4] Hyogo Coll Med, Dept Cardiovasc & Renal Med, Nishinomiya, Hyogo, Japan

[5] Sakurabashi Watanabe Hosp, Div Cardiol, Osaka, Japan

[6] New Tokyo Hosp, Dept Cardiol, Chiba, Japan

[7] Okinawa Prefectural Nanbu Med Ctr & Childrens Med, Dept Cardiol, Haebaru, Okinawa, Japan

[8] Shin Koga Hosp, Cardiovasc Ctr, Dept Cardiol, Fukuoka, Japan

[9] Oita Univ, Fac Med, Dept Cardiol & Clin Examinat & Diag, Oita, Japan

[10] Kitasato Univ, Dept Cardiovasc Med, Sch Med, Sagamihara, Kanagawa, Japan

[11] Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan

[12] Japan Community Hlth Care Org JCHO, Div Cardiol, Chukyo Hosp, Nagoya, Aichi, Japan

[13] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan

[14] Univ Tsukuba, Fac Med, Dept Cardiol, Tsukuba, Ibaraki, Japan

[15] Himeji Cardiovasc Ctr, Dept Cardiol, Himeji, Hyogo, Japan

[16] Univ Fukui, Fac Med Sci, Dept Cardiovasc Med, Fukui, Japan

[17] Yokohama City Univ Med, Dept Cardiol, Yokohama, Kanagawa, Japan

[18] Japanese Red Cross Kumamoto Hosp, Dept Cardiol, Kumamoto, Japan

[19] Itabashi Chuo Med Ctr, Dept Cardiovasc Med, Tokyo, Japan

[20] Japanese Red Cross Fukuoka Hosp, Dept Cardiol, Fukuoka, Japan

[21] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Cardiovasc Med, Hiroshima, Japan

[22] Medtronic Inc, Minneapolis, MN USA

[23] Medtron Japan Co Ltd, Tokyo, Japan

来源：

CIRCULATION JOURNAL | 2020年 / 84卷 / 07期

关键词：

Heart failure; Hospitalization; Implantable device diagnostics; Risk stratification; ATRIAL-FIBRILLATION; VALIDATION;

D O I：

10.1253/circj.CJ-19-1143

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Integrated device diagnostics, Triage-HF, is useful in risk stratifying patients with heart failure (HF), but its performance for Japanese patients remains unknown. This is a prospective study of Japanese patients treated with a cardiac resynchronization therapy defibrillator (CRT-D), with a Medtronic OptiVol 2.0 feature. Methods and Results: A total of 320 CRT-D patients were enrolled from 2013 to 2017. All received HF treatment in the prior 12 months. Following enrollment, they were followed every 6 months for 48 months (mean, 22 months). Triage-HF-stratified patients at low, medium and high risk statuses at every 30-day period, and HF-related hospitalization occurring for the subsequent 30 days, were evaluated and repeated. The primary endpoint was to assess Triage-HF performance in predicting HF-related hospitalization risk. All device data were available for 279 of 320 patients (NYHA class II or III in 93%; mean left ventricular ejection fraction, 31%). During a total of 5,977 patient-month follow-ups, 89 HF-related hospitalization occurred in 72 patients. The unadjusted event numbers for Low, Medium and High statuses were 19 (0.7%), 42 (1.6%) and 28 (4.1%), respectively. Relative risk of Medium to Low status was 2.18 (95% CI 1.23-3.85) and 5.78 (95% CI 3.34-10.01) for High to Low status. Common contributing factors among the diagnostics included low activity, OptiVol threshold crossing, and elevated night heart rate. Conclusions: Triage-HF effectively stratified Japanese patients at risk of HF-related hospitalization.

引用

页码：1118 / 1123

页数：6

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