Pulmonary Edema in COVID19-A Neural Hypothesis

被引:18
作者
Anoop, U. R. [1 ]
Verma, Kavita [1 ]
机构
[1] UR Anoop Res Grp, Pondicherry 605008, India
关键词
COVID-19; Nucleus tractus solitarius; Catecholamine storm; Brain trigger zones; Neurogenic pulmonary edema; Microvascular clotting;
D O I
10.1021/acschemneuro.0c00370
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Currently, these manifestations are considered to be only consequences of pulmonary SARS-CoV-2 virus infection. We are proposing a new hypothesis that neurogenic insult may also play a major role in the pathogenesis of these manifestations. SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius (NTS) may play a role in the acute exacerbation of pulmonary edema and microvascular clotting in COVID-19 patients.
引用
收藏
页码:2048 / 2050
页数:3
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