Altered hyaluronan biosynthesis in cancer progression

被引：84

作者：

Itano, Naoki ^{[2
,3
]}

Kimata, Koji ^{[1
]}

机构：

[1] Aichi Med Univ, Inst Mol Sci Med, Aichi 4801195, Japan

[2] Shinshu Univ, Grad Sch Med, Inst Aging & Adaptat, Dept Mol Oncol,Div Mol & Cellular Biol, Nagano 3908621, Japan

[3] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan

来源：

SEMINARS IN CANCER BIOLOGY | 2008年 / 18卷 / 04期

基金：

日本科学技术振兴机构;

关键词：

hyaluronan; biosynthesis; cancer progression; angiogenesis; extracellular matrix; stroma;

D O I：

10.1016/j.semcancer.2008.03.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Microenvironmental stimuli can influence the malignant phenotype of cancer cells. Notably, the altered biosynthesis of hyaluronan, a constituent of the extracellular microenvironment, has been implicated in the progress and metastasis of carcinomas. The discovery of hyaluronan synthase (HAS) genes, which encode the key enzymes in hyaluronan biosynthesis, has enabled great strides in understanding the mechanism, underlying altered hyaluronan production in cancer and the involvement of this polysaccharide in tumor progression. Recent studies using HAS transgenic mice have provided evidence that overproduction of hyaluronan in mammary tumors accelerates tumor growth through the recruitment of stromal cells and vasculature, revealing further insight into how increased hyaluronan influences the malignant behaviors of cancer cells. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：268 / 274

页数：7

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