Micro/nanofluidics-enabled single-cell biochemical analysis

被引：40
作者：
Lin, Ling [1 ,2 ]
Chen, Qinghua [1 ,2 ]
Sun, Jiashu [1 ,2 ]
机构：
[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2018年 / 99卷
关键词：
Single cell; Microfluidics; Nanofluidics; Biochemical analysis; Nanospace; WHOLE-GENOME AMPLIFICATION; GLASS NANOFLUIDIC CHIPS; CIRCULATING TUMOR-CELLS; TOTAL ANALYSIS SYSTEMS; EXTENDED-NANO CHANNEL; OPTICAL TWEEZERS; LIQUID-CHROMATOGRAPHY; MICROFLUIDIC DEVICE; INTRACELLULAR MOLECULES; FEMTOSECOND LASER;
D O I：
10.1016/j.trac.2017.11.017
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The micro/nanofluidic technique has become an important tool for single-cell analysis with the capability to integrate time-consuming and labour-intensive experimental procedures into a small device. Micro/nanofluidics-based biochemical analysis exhibits advantages over conventional methods in terms of small sample volume, rapid turnaround time, straightforward operation, and efficient processing. Single-cell manipulation, therapy, detection and sequencing could be implemented within a sophisticated and multi-functional micro/nanofluidic platform. Here we review recent developments of micro/nanofluidic technologies for single-cell analysis, with emphasis on cell trapping, treatment, and biochemical studies. The potential of micro/nanofluidics-based single-cell analysis is discussed. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：66 / 74
页数：9
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