Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia

被引：13

作者：

Azuma, Y ^{[1
]}

Ohura, K ^{[1
]}

Wang, PL ^{[1
]}

Shinohara, M ^{[1
]}

机构：

[1] Osaka Dent Univ, Dept Pharmacol, Osaka 5731121, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 01期

基金：

日本学术振兴会;

关键词：

endomorphins; microglia; phagocytosis; chemotaxis; superoxide anion;

D O I：

10.1016/S0165-5728(01)00363-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluate the role of endomorphins 1 and 2 on microglial functions. Endomorphins 1 and 2 blocked phagocytosis of Escherichia coli. In addition, both markedly inhibited chemotaxis toward zymosan-activated serum. In contrast, when microglia was preincubated with these endomorphins, followed by incubation with LPS before stimulation with phorbol 12-myristate 13-acetate (PMA) at 200 nM, they potentiated superoxide anion production. Furthermore, when microglia was preincubated with these endomorphins together with PMA at 20 nM, followed by stimulation with PMA at 200 nM, superoxide anion production was potentiated. These results suggest that endomorphins 1 and 2 modulate phagocytosis. chemotaxis and superoxide anion production by microglia. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：51 / 56

页数：6

共 39 条

[1] HOW CYTOKINES SIGNAL MESSAGES WITHIN CELLS [J].