Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease

被引：27
作者：
Steinke, John W. [1 ]
Payne, Spencer C. [2 ,3 ]
Borish, Larry [1 ,4 ]
机构：
[1] Univ Virginia Hlth Syst, Dept Med, Asthma & Allerg Dis Ctr, Carter Ctr Immunol Res, 409 Lane Rd, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Med, 409 Lane Rd, Charlottesville, VA 22908 USA
[3] Univ Virginia Hlth Syst, Dept Otolaryngol Head & Neck Surg, 409 Lane Rd, Charlottesville, VA 22908 USA
[4] Univ Virginia Hlth Syst, Carter Ctr Immunol Res, Asthma & Allerg Dis Ctr, Dept Microbiol, 409 Lane Rd, Charlottesville, VA 22908 USA
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 04期
关键词：
Eosinophil; Mast cell; Leukotriene; Cyclooxygenase; Prostaglandin; Aspirin-exacerbated respiratory disease; Arachidonic acid; CYSTEINYL-LEUKOTRIENE RECEPTOR; CHRONIC HYPERPLASTIC SINUSITIS; SENSITIVE ASTHMATIC SUBJECTS; MUCOSAL INFLAMMATORY CELLS; E-PROSTANOID; PROSTAGLANDIN D-2; NASAL POLYPOSIS; IFN-GAMMA; CHRONIC RHINOSINUSITIS; INTOLERANT ASTHMA;
D O I：
10.1016/j.iac.2016.06.008
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Aspirin-exacerbated respiratory disease (AERD) involves overexpression of proinflammatory mediators, including 5-lipoxygenase and leukotriene 04 synthase (LTC4S), resulting in constitutive overproduction of cysteinyl leukotrienes. Mast cells and eosinophils have roles in mediating many of the observed effects. Increased levels of both interleukin-4 (IL-4) and interferon (IFN)-gamma are present in the tissue of patients with AERD. Previous studies showed that IL-4 is primarily responsible for the upregulation of LTC4S by mast cells. Our studies show that IFN-gamma, but not IL-4, drives this process in eosinophils. This article examines the overall role that eosinophils and mast cells contribute to the pathophysiology of AERD.
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页码：719 / +
页数：17
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