Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit

被引：0

作者：

Noreen, Shabana ^{[1
]}

Shaheen, Ghazala ^{[1
]}

Akram, Muhammad ^{[2
]}

Rashid, Abid ^{[3
]}

Shah, Syed Muhammad Ali ^{[4
]}

机构：

[1] Islamia Univ Bahawalpur, Univ Coll Convent Med, Dept Eastern Med & Surg, Bahawalpur, Pakistan

[2] Univ Poonch, Fac Med & Hlth Sci, Dept Eastern Med & Surg, Rawalakot, Azad Kashmir, Pakistan

[3] GC Univ, Directorate Med Sci, Faisalabad, Pakistan

[4] GC Univ, Dept Eastern Med & Surg, Directorate Med Sci, Faisalabad, Pakistan

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 29卷 / 04期

关键词：

Vaccinium macrocarpon; antiurease activity; anti-oxidant activity; UREASE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0 +/- 1.15 activity but the activity was less than ascorbic acid i.e. 93.74 +/- 0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00 +/- 0.2a) with IC50 (392.66 +/- 2.1) followed by aqueous fraction (68.00 +/- 0.5e) with IC50 (159.83 +/- 2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities.

引用

页码：1383 / 1385

页数：3

共 11 条

[1] Catalytic properties of the immobilized Aspergillus tamarii xylanase
Gouda, MK
Abdel-Naby, MA
[J]. MICROBIOLOGICAL RESEARCH, 2002, 157 (04) : 275 - 281
[2] Bacterial Urease and its Role in Long-Lasting Human Diseases
Konieczna, Iwona
Zarnowiec, Paulina
Kwinkowski, Marek
Kolesinska, Beata
Fraczyk, Justyna
Kaminski, Zbigniew
Kaca, Wieslaw
[J]. CURRENT PROTEIN & PEPTIDE SCIENCE, 2012, 13 (08) : 789 - 806
[3] Lateef M, 2012, PAK J PHARM SCI, V25, P99
[4] Lobo V, 2010, Pharmacogn Rev, V4, P118, DOI 10.4103/0973-7847.70902
[5] Lydia E, 2010, CLIN MICROBIOL REV, V23, P713
[6] The variation in antimicrobial and antioxidant activities of acetone leaf extracts of 12 Moringa oleifera (Moringaceae) trees enables the selection of trees with additional uses
Ratshilivha, N.
Awouafack, M. D.
du Toit, E. S.
Eloff, J. N.
[J]. SOUTH AFRICAN JOURNAL OF BOTANY, 2014, 92 : 59 - 64
[7] Sanaz G, 2013, DARU, V21, P2
[8] Antioxidant and anti proliferative activities of common fruits
Sun, J
Chu, YF
Wu, XZ
Liu, RH
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (25) : 7449 - 7454
[9] Biosensors in food processing
Thakur, M. S.
Ragavan, K. V.
[J]. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2013, 50 (04): : 625 - 641
[10] Cranberries and cranberry products: Powerful in vitro, ex vivo, and in vivo sources of antioxidants
Vinson, Joe A.
Bose, Pratima
Proch, John
Al Kharrat, Hassan
Samman, Najwa
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (14) : 5884 - 5891

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