Ofatumumab treatment in lupus nephritis patients

被引：40

作者：

Haarhaus, Malena Loberg ^{[1
]}

Svenungsson, Elisabet ^{[1
]}

Gunnarsson, Iva ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden

来源：

CLINICAL KIDNEY JOURNAL | 2016年 / 9卷 / 04期

关键词：

infusion reactions; lupus nephritis; ofatumumab; rituximab; systemic lupus erythematosus; B-CELL DEPLETION; DOUBLE-BLIND; TERM EFFICACY; RITUXIMAB; ERYTHEMATOSUS; SAFETY; TRIAL; ANTIBODY;

D O I：

10.1093/ckj/sfw022

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Rituximab is frequently used in systemic lupus erythematosus; however, side effects such as infusion-related reactions limit its use. In this case report, we describe, for the first time, treatment with ofatumumab in four patients with lupus nephritis. The treatment was well tolerated in three of the patients, and a reduction of proteinuria was seen in all cases. This emphasizes the importance of alternative B-cell-depleting therapies in patients with an initial good response to rituximab, but who develop side effects.

引用

页码：552 / 555

页数：4

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