Directing CAR T cells towards the tumor vasculature for the treatment of solid tumors

被引：30

作者：

Akbari, Parvin ^{[1
]}

Katsarou, Afroditi ^{[1
]}

Daghighian, Roxanna ^{[1
]}

van Mil, Lotte W. H. G. ^{[1
]}

Huijbers, Elisabeth J. M. ^{[1
]}

Griffioen, Arjan W. ^{[1
]}

van Beijnum, Judy R. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam UMC,Angiogenesis Lab, Amsterdam, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 03期

关键词：

Cancer; CAR T cell; Immune suppression; Tumor microenvironment; Angiogenesis; CHIMERIC ANTIGEN RECEPTOR; INDOLEAMINE 2,3-DIOXYGENASE; GENE-EXPRESSION; CANCER REGRESSION; IMMUNOTHERAPY; ANGIOGENESIS; LYMPHOCYTES; AFFINITY; THERAPY; RECOGNITION;

D O I：

10.1016/j.bbcan.2022.188701

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For successful application of chimeric antigen receptor (CAR) T cell therapy in solid tumors, major hurdles have to be overcome. CAR T cells have to cross the vascular barrier, which is hampered by the anergic state of the tumor vasculature, characterized by suppressed levels of leukocyte adhesion molecules on the endothelium. Additional immunosuppressive mechanisms in the solid tumor microenvironment can affect infiltration, activity and persistence of CAR T cells. Redirecting CAR T cells towards the tumor vasculature poses a possible solution, as molecular targets of tumor endothelial cells can be directly engaged from within the blood.In this review, we discuss recent advances in CAR T cell therapy against solid tumors, with a focus on targeting the tumor vasculature. Furthermore, we discuss opportunities to overcome challenges and barriers through engineering of CAR T cells to enhance trafficking, safety and efficacy.

引用

页数：11

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