Functionalization and molecular dynamics study of carboxy-terminated poly(1-vinylpyrrolidin-2-one): A potential soluble carrier of biomolecules

被引：7

作者：

Baldoli, Clara ^{[3
]}

Oldani, Claudio ^{[1
,2
]}

Maiorana, Stefano ^{[1
,2
]}

Ferruti, Paolo ^{[1
,2
]}

Ranucci, Elisabetta ^{[1
,2
]}

Bencini, Marco ^{[1
,2
]}

Contini, Alessandro ^{[4
]}

机构：

[1] Univ Milan, Dept Organ & Ind Chem, I-20133 Milan, Italy

[2] Univ Milan, Ctr Excellence CISI, I-20133 Milan, Italy

[3] CNR, Inst Mol Sci & Technol, I-20133 Milan, Italy

[4] Univ Milan, Inst Organ Chem Alessandro Marchesini, I-20133 Milan, Italy

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2008年 / 46卷 / 05期

关键词：

computer modeling; functionalization of polymers; MALDI; molecular dynamics; PVP; water-soluble polymers;

D O I：

10.1002/pola.22510

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The reactivity of carboxy-terminated poly(1-vinylpyrrolidin-2-one) (PVP-COOH) 40-mers 1 with various small bi-functionalized molecules has been investigated. A number of new differently functionalized. PVP 3-11 have been successfully obtained demonstrating that the presence of the bulky PVP chain did not hamper the reactivity of the carboxy group. This would imply that in solution the carboxyl group is not buried inside the coil, but well exposed to the solvent, as further confirmed by a molecular dynamics conformational study. (c) 2008 Wiley Periodicals, Inc.

引用

页码：1683 / 1698

页数：16

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