Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata

被引：8

作者：

Gorshkova, IA ^{[1
]}

Gorshkov, BA ^{[1
]}

Fedoreev, SA ^{[1
]}

Shestak, OP ^{[1
]}

Novikov, VL ^{[1
]}

Stonik, VA ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Div, Vladivostok 690022, Russia

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1999年 / 122卷 / 01期

关键词：

halenaquinol; inhibition; marine organisms; Na+; K+-ATPase; Ca2+-ATPase; rat brain; sarcoplasmic reticulum; sponge natural products; Petrosia seriata;

D O I：

10.1016/S0742-8413(98)10084-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata, was found to be a powerful inhibitor of the rat brainstem and of the rat brain cortex Na+, K+-ATPases and the rabbit muscle sarcoplasmic reticulum Ca2+-ATPase with I-50 values of 7.0 x 10(-7), 1.3 x 10(-6) and 2.5 x 10(-6) M, respectively. Halenaquinol also inhibited K+-phosphatase activity of the rat brain cortex Na+, K+-ATPase with an I-50 value of 3 x 10(-6) M. Ouabain-insensitive Mg2+-ATPase activity of the microsomal fraction of the rat brain cortex was weakly inhibited by halenaquinol. Inhibition was irreversible, dose- and time-dependent. Naphthohydroquinone fragment in structures of halenaquinol, related natural and model compounds was very important for an inhibiting effect. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：93 / 99

页数：7

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