Common polymorphisms in antioxidant genes are associated with diabetic nephropathy in Type 2 diabetes patients

被引：0

作者：

Klen, Jasna ^{[1
]}

Goricar, Katja ^{[2
]}

Janez, Andrej ^{[3
]}

Dolzan, Vita ^{[2
]}

机构：

[1] Gen Hosp Trbovlje, Trbovlje 1420, Slovenia

[2] Univ Ljubljana, Fac Med, Inst Biochem, Pharmacogenet Lab, Vrazov Trg 2, Ljubljana 1000, Slovenia

[3] Univ Med Ctr Ljubljana, Dept Endocrinol Diabet & Metab Dis, Ljubljana 1000, Slovenia

来源：

PERSONALIZED MEDICINE | 2015年 / 12卷 / 03期

关键词：

antioxidative enzymes; CAT; genetic polymorphism; GSTP1; oxidative stress; Type; 2; diabetes; MANGANESE SUPEROXIDE-DISMUTASE; INTENSIVE GLUCOSE CONTROL; S-TRANSFERASES GENOTYPES; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS; KIDNEY-DISEASE; SUBUNIT GENE; VARIANTS; MELLITUS;

D O I：

10.2217/PME.14.86

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: To investigate if antioxidative genes' polymorphisms influence the risk for Type 2 diabetes (T2D) complications. Materials & Methods: In total, 181 T2D patients were genotyped for SOD2, CAT, GPX1, GSTP1, GSTM1*0, GSTT1*0, GCLC and GCLM. Results: After adjustment for duration of T2D, CAT rs1001179 and GSTP1 rs1138272 showed strongest association with risk for end-stage kidney failure (p = 0.005 and p = 0.049, respectively). In patients without end-stage kidney failure CAT rs1001179 influenced urea levels (p = 0.003), while GSTP1 rs1695 and GSTP1 haplotypes influenced the risk of moderately increased albuminuria (p = 0.024 and p = 0.014, respectively). Conclusion: Common CAT and GSTP1 polymorphisms could be used to identify T2D patients at an increased risk for developing end-stage kidney failure.

引用

页码：187 / 198

页数：12