A case of Beh‡et's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab

被引：95

作者：

Hirano, Toru ^{[1
]}

Ohguro, Nobuyuki ^{[2
]}

Hohki, Satoshi ^{[3
]}

Hagihara, Keisuke ^{[1
]}

Shima, Yoshihito ^{[1
]}

Narazaki, Masashi ^{[1
]}

Ogata, Atsushi ^{[1
]}

Yoshizaki, Kazuyuki ^{[4
]}

Kumanogoh, Atsushi ^{[1
]}

Kishimoto, Tadamitsu ^{[5
]}

Tanaka, Toshio ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Resp Med Allergy & Rheumat Dis, Suita, Osaka 5650871, Japan

[2] Osaka Koseinenkin Hosp, Dept Ophthalmol, Osaka, Japan

[3] Toyama Univ, Dept Ophthalmol, Grad Sch Med & Pharmaceut Sci, Toyama 930, Japan

[4] Osaka Univ, Ctr Adv Sci & Innovat, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Lab Immune Regulat, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

来源：

MODERN RHEUMATOLOGY | 2012年 / 22卷 / 02期

关键词：

Behcet's disease; IL-6; Tocilizumab; GENOME-WIDE ASSOCIATION; BEHCETS-DISEASE; CEREBROSPINAL-FLUID; INTERLEUKIN-6; IL23R-IL12RB2; GENERATION; THERAPY; CELLS; IL10;

D O I：

10.1007/s10165-011-0497-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 47-year-old female patient with Beh double dagger et's disease had been treated with colchicine, prednisolone, cyclosporine A, and infliximab. Because she relapsed, however, treatment with tocilizumab, a humanized anti-interleukin 6 receptor antibody, was started. This treatment suppressed the patient's clinical manifestations, including ocular attacks, for 1 year and improved her visual acuity. This experience indicates that tocilizumab may constitute a therapeutic option for refractory Beh double dagger et's disease.

引用

页码：298 / 302

页数：5

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