Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

被引：6
|
作者：
Pei, Yuanchao [1 ]
Zhang, Jianzhou [2 ]
Song, Xinxin [1 ]
Zhao, Ming [1 ]
Wang, Jianji [1 ]
机构：
[1] Henan Normal Univ, Minist Educ, Key Lab Green Chem Media & React, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
[2] Luoyang Inst Sci & Technol, Dept Environm Engn & Chem, Luoyang, Henan, Peoples R China
来源：
SEPARATION SCIENCE AND TECHNOLOGY | 2015年 / 50卷 / 11期
基金：
中国国家自然科学基金;
关键词：
cholinium-based ionic liquid; extraction; drug molecules; EXTRACTION; SEPARATION; SOLVENTS; SYSTEMS;
D O I：
10.1080/01496395.2014.978475
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this paper, a series of ionic liquids (ILs) contains cholinium as cations were prepared. These ILs were used as extractants to separate some model drug molecules. The partition coefficients of these drug molecules between ILs and aqueous solutions were determined. Furthermore, the influence of different extraction parameters was investigated: volume ratio, equilibrium time, pH values, temperature, and ILs structure. It is shown that these ILs are highly effective materials for the extraction of drug molecules. The results imply that these ILs may have potential in drug extraction or separation as a new type of media.
引用
收藏
页码：1641 / 1646
页数：6
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