Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

被引：6

作者：

Pei, Yuanchao ^{[1
]}

Zhang, Jianzhou ^{[2
]}

Song, Xinxin ^{[1
]}

Zhao, Ming ^{[1
]}

Wang, Jianji ^{[1
]}

机构：

[1] Henan Normal Univ, Minist Educ, Key Lab Green Chem Media & React, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

[2] Luoyang Inst Sci & Technol, Dept Environm Engn & Chem, Luoyang, Henan, Peoples R China

来源：

SEPARATION SCIENCE AND TECHNOLOGY | 2015年 / 50卷 / 11期

基金：

中国国家自然科学基金;

关键词：

cholinium-based ionic liquid; extraction; drug molecules; EXTRACTION; SEPARATION; SOLVENTS; SYSTEMS;

D O I：

10.1080/01496395.2014.978475

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, a series of ionic liquids (ILs) contains cholinium as cations were prepared. These ILs were used as extractants to separate some model drug molecules. The partition coefficients of these drug molecules between ILs and aqueous solutions were determined. Furthermore, the influence of different extraction parameters was investigated: volume ratio, equilibrium time, pH values, temperature, and ILs structure. It is shown that these ILs are highly effective materials for the extraction of drug molecules. The results imply that these ILs may have potential in drug extraction or separation as a new type of media.

引用

页码：1641 / 1646

页数：6

共 50 条

[1] Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules
Kurnik, Isabelle S.
D'Angelo, Natalia A.
Mazzola, Priscila G.
Chorilli, Marlus
Kamei, Daniel T.
Pereira, Jorge F. B.
Vicente, Antonio A.
Lopes, Andre M.
BIOMATERIALS SCIENCE, 2021, 9 (06) : 2183 - 2196
[2] Cholinium-based ionic liquids with pharmaceutically active anions
Araujo, Joao M. M.
Florindo, Catarina
Pereiro, Ana B.
Vieira, Nicole S. M.
Matias, Ana A.
Duarte, Catarina M. M.
Rebelo, Luis P. N.
Marrucho, Isabel M.
RSC ADVANCES, 2014, 4 (53): : 28126 - 28132
[3] Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation
Sintra, Tania E.
Abranches, Dinis O.
Benfica, Jordana
Soares, Bruna P.
Ventura, Sonia P. M.
Coutinho, Joao A. P.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021, 164 : 86 - 92
[4] New low viscous cholinium-based magnetic ionic liquids
Rosatella, Andreia A.
Siopa, Filipa
Frade, Raquel F. M.
Afonso, Carlos A. M.
NEW JOURNAL OF CHEMISTRY, 2016, 40 (04) : 3124 - 3129
[5] Influence of cholinium-based ionic liquids on the structural stability and activity of α-chymotrypsin
Bisht, Meena
Venkatesu, Pannuru
NEW JOURNAL OF CHEMISTRY, 2017, 41 (22) : 13902 - 13911
[6] Novel biocompatible cholinium-based ionic liquids-toxicity and biodegradability
Petkovic, Marija
Ferguson, Jamie L.
Gunaratne, H. Q. Nimal
Ferreira, Rui
Leitao, Maria C.
Seddon, Kenneth R.
Rebelo, Luis Paulo N.
Pereira, Cristina Silva
GREEN CHEMISTRY, 2010, 12 (04) : 643 - 649
[7] Influence of carboxyl anion on the dissolution of chitosan in cholinium-based ionic liquids
Liu, Dong
Chen, Qingtai
Li, Min
Lou, Bin
Yu, Ran
Li, Zhiheng
Zhang, Yadong
MATERIALS SCIENCE, ENERGY TECHNOLOGY AND POWER ENGINEERING II (MEP2018), 2018, 1971
[8] Development of Cholinium-Based API Ionic Liquids with Enhanced Drug Solubility: Biological Evaluation and Interfacial Properties
Bhat, Ab Raouf
Padder, Rayees Ahmed
Husain, Mohammad
Patel, Rajan
MOLECULAR PHARMACEUTICS, 2024, 21 (02) : 535 - 549
[9] Towards understanding of delignification of grassy and woody biomass in cholinium-based ionic liquids
Mohan, Mood
Choudhary, Hemant
George, Anthe
Simmons, Blake A.
Sale, Kenneth
Gladden, John M.
GREEN CHEMISTRY, 2021, 23 (16) : 6020 - 6035
[10] Synthesis and Thermophysical Properties of Biocompatible Cholinium-Based Amino Acid Ionic Liquids
Tao, Duan-Jian
Cheng, Zheng
Chen, Feng-Feng
Li, Zhang-Min
Hu, Na
Chen, Xiang-Shu
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2013, 58 (06): : 1542 - 1548

← 1 2 3 4 5 →