Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes

被引：0

作者：

Lopatina, LP ^{[1
]}

Wasseem, TV ^{[1
]}

Fedorovich, S ^{[1
]}

Konev, S ^{[1
]}

机构：

[1] Natl Acad Sci, Inst Biophys & Cell Engn, Minsk 220072, BELARUS

来源：

BIOFIZIKA | 2005年 / 50卷 / 06期

关键词：

synaptosomes; gadolinium; lanthanum; eyocytosis; acridine orange; neurotransmitter release;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The influence of lanthanoids on exocytosis was investigated. It was shown that gadolinium increases the spontaneous release of the glutamate nonmetabolizing analogue [H-3]D-aspartate. It was established using the fluorescent dye acridine orange that gadolinium and lanthanum induce exocytosis. The effect was dose-dependent and was maximum at 300 mu M Gd3+. The exocytosis induced by gadolinium was calcium-independent. It is suggested that lanthanides induce a vesicular release of neurotransmitters by the mechanisms common for all polyvalent cations.

引用

页码：1120 / 1124

页数：5

共 19 条

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