Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis

被引：13
作者：
El-Seedi, Hesham R. [1 ,2 ,3 ]
El-Shabasy, Rehan [3 ]
Sakr, Hanem [3 ]
Zayed, Mervat [3 ]
El-Said, Asmaa M. A. [3 ]
Helmy, Khalid M. H. [3 ]
Gaara, Ahmed H. M. [4 ]
Turki, Zaki [5 ]
Azeem, Muhammad [2 ]
Ahmed, Ahmed M.
Boulos, Loutfy [6 ]
Borg-Karlson, Anna-Karin [2 ]
Goransson, Ulf
机构：
[1] Uppsala Univ, Div Pharmacognosy, Dept Med Chem, Biomed Ctr, SE-75123 Uppsala, Sweden
[2] Royal Inst Technol KTH, Dept Chem, Stockholm, Sweden
[3] Menoufia Univ, Fac Sci, Dept Chem, Menoufia, Egypt
[4] Natl Res Ctr, Cairo, Egypt
[5] Menoufia Univ, Fac Sci, Dept Bot, Menoufia, Egypt
[6] Univ Alexandria, Fac Sci, Dept Bot, Alexandria, Egypt
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2012年 / 22卷 / 02期
基金：
瑞典研究理事会;
关键词：
anti-schistosomiasis; Asparagus stipularis; Asparagaceae; triterpene glycoside; STEROIDAL SAPONINS;
D O I：
10.1590/S0102-695X2012005000004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided isolation using an in vitro assay testing for anti-schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 mu g/mL concentration.
引用
收藏
页码：314 / 318
页数：5
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