Preparation of nanoparticles embedded microcapsules (NEMs) and their application in drug release

被引：20

作者：

Liu, Yuangang ^{[1
,2
]}

Sun, Xuezhan ^{[1
,2
]}

Wang, Shibin ^{[1
,2
]}

Xie, Maobin ^{[1
,2
]}

Chen, Aizheng ^{[1
,2
]}

Long, Ruimin ^{[1
]}

机构：

[1] Huaqiao Univ, Coll Chem Engn, Xiamen 361021, Peoples R China

[2] Huaqiao Univ, Inst Biomat & Tissue Engn, Xiamen 361021, Peoples R China

来源：

MATERIALS LETTERS | 2012年 / 75卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Composite materials; Nanoparticles; Microcapsules; Drug release; MICROENCAPSULATION; NANOSPHERES; ALGINATE;

D O I：

10.1016/j.matlet.2012.01.137

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The strategy to construct a novel drug delivery system of nanoparticle embedded microcapsules (NEMs) is reported in this work. The Chitosan/Alginate Nanoparticle Embedded Microcapsules (CS/Alg NEMs) have been successfully prepared by emulsion-gelation and high-voltage electrostatic droplet generator. The drug release behavior in vitro of the NEMs was studied, using Capecitabine (CAP) and gamma-globulin as model drugs. The results demonstrated that the NEMs could control the drugs' release rate significantly, whether it is a small-molecular drug or peptide and protein. Also, the results indicated that the co-loading drugs exhibited an orderly release property. The NEMs exhibited a great potential for application in drug delivery for multi-functions and sustained release. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：48 / 50

页数：3

共 17 条

[1] Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect [J].