The development of LTi cells

被引：54

作者：

Cherrier, Marie ^{[1
,2
]}

Eberl, Gerard ^{[1
,2
]}

机构：

[1] Inst Pasteur, Lymphoid Tissue Dev Unit, F-75724 Paris, France

[2] CNRS, URA1961, F-75015 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 02期

关键词：

ROR-GAMMA-T; INNATE LYMPHOID-CELLS; TISSUE-INDUCER CELLS; NATURAL-KILLER-CELLS; CYTOKINE GM-CSF; PROINFLAMMATORY IL-17(+); INTESTINAL HOMEOSTASIS; EPITHELIAL-CELLS; PEYERS-PATCHES; RECEPTOR-ALPHA;

D O I：

10.1016/j.coi.2012.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor ROR gamma t. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of ROR gamma t in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.

引用

页码：178 / 183

页数：6

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