Metabolic Alterations Within the Primary Visual Cortex in Early Open-angle Glaucoma Patients: A Proton Magnetic Resonance Spectroscopy Study

被引：9

作者：

Guo, Linying ^{[1
]}

Wang, Rong ^{[1
]}

Tang, Zuohua ^{[1
]}

Sun, Xinghuai ^{[3
,4
,5
,6
]}

Wu, Lingjie ^{[2
]}

Wang, Jie ^{[2
]}

Zhong, Yufeng ^{[1
,7
]}

Xiao, Zebin ^{[1
]}

Zhang, Zhongshuai ^{[8
]}

机构：

[1] Fudan Univ, Dept Radiol, Shanghai, Peoples R China

[2] Fudan Univ, Dept Otolaryngol, Shanghai, Peoples R China

[3] Fudan Univ, Eye & ENT Hosp, Shanghai Med Sch, Dept Ophthalmol & Visual Sci, Shanghai, Peoples R China

[4] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China

[5] Fudan Univ, NHFPC, Key Lab Myopia, Shanghai, Peoples R China

[6] Fudan Univ, Shanghai Key Lab Visual Impairment & Restorat, Shanghai, Peoples R China

[7] Fudan Univ, Jinshan Hosp, Shanghai Med Sch, Dept Radiol, Shanghai, Peoples R China

[8] Siemens Healthcare Ltd, Shanghai, Peoples R China

来源：

JOURNAL OF GLAUCOMA | 2018年 / 27卷 / 12期

基金：

中国国家自然科学基金;

关键词：

open-angle glaucoma; magnetic resonance spectroscopy; primary visual cortex; cortical plasticity; OPTIC-NERVE; INTRAOCULAR-PRESSURE; FMRI MEASUREMENTS; BRAIN; GLUTAMATE; INJURY; DAMAGE; MODEL; CYCLE; FIELD;

D O I：

10.1097/IJG.0000000000001098

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To detect changes in metabolites and explore cortical plasticity at the metabolic level within the primary visual cortex through proton magnetic resonance spectroscopy in early open-angle glaucoma (OAG) patients. Methods: A total of 23 symmetrically bilateral early OAG patients and 21 normal controls (NC) were recruited as the early OAG group and NC group, respectively. All subjects underwent a proton magnetic resonance examination, and then, the N-acetylaspartate (NAA), glutamine-glutamate (Glx), myo-inositol (Ins), choline (Cho), and creatine (Cr) concentrations within the bilateral primary visual cortex were determined. The mean NAA/Cr ratio, mean Cho/Cr ratio, mean Glx/Cr ratio, and mean Ins/Cr ratio of the bilateral sides were compared between early OAG patients and NC using the independent samples t test. Results: Compared with NC, the mean Glx/Cr ratio (corrected P=0.003) in primary visual cortex was significantly higher, whereas the mean Ins/Cr ratio (corrected P=0.001) was statistically lower in early OAG patients. However, no apparent difference was found in the mean Cho/Cr ratio or mean NAA/Cr ratio between the OAG group and NC group. Conclusions: Abnormal metabolites were found in our study through proton magnetic resonance spectroscopy and could contribute to cortical plasticity of the primary visual cortex in early OAG patients.

引用

页码：1046 / 1051

页数：6

共 44 条

[31] Functional MRI Signal Changes in Primary Visual Cortex Corresponding to the Central Normal Visual Field of Patients with Primary Open-Angle Glaucoma [J].