Rosin nanoparticles as a drug delivery carrier for the controlled release of hydrocortisone

被引：36

作者：

Lee, CM

Lim, S

Kim, GY

Kim, DW

Rhee, J

Lee, KY ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Appl Chem Engn, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Interdisciplinary Program Biomed Engn, Kwangju 500757, South Korea

[3] Chonnam Natl Univ, Ecobio Inc, Business Incubat Ctr, Kwangju 500757, South Korea

[4] Gwang Yang Hlth Coll, Dept Clin Pathol, Jeonnam 545703, South Korea

[5] Chonnam Natl Univ, Sch Med, Dept Microbiol, Kwangju 501190, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 19期

关键词：

drug release; hydrocortisone; nanoparticle; rosin gum;

D O I：

10.1007/s10529-005-1316-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167-332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.

引用

页码：1487 / 1490

页数：4

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