Mg-Catalyzed Enantioselective Benzylic C-H Bond Functionalization of Isoindolinones: Addition to Imines

被引：17

作者：

Suzuki, Yudai ^{[1
]}

Kanai, Motomu ^{[1
,2
]}

Matsunaga, Shigeki ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy, Kanai Life Sci Catalysis Project, ERATO, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 25期

关键词：

asymmetric catalysis; C?H activation; imines; isoindolinones; magnesium; MANNICH-TYPE REACTIONS; SCHIFF-BASE CATALYSIS; CHIRAL CARBON STEREOCENTERS; ASYMMETRIC-SYNTHESIS; MESO-AZIRIDINES; OXINDOLES; ISOINDOLIN-1-ONES; CONSTRUCTION; 2,3-DIHYDRO-1H-ISOINDOL-1-ONES; STEREOCONTROLLER;

D O I：

10.1002/chem.201200821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Access to chiral isoindolinones: The Mg-catalyzed enantioselective benzylic CH bond functionalization of isoindolinones is described. A Bu2Mg/Schiff base catalyst (1:1) promoted the enantioselective addition of N-Boc-isoindolinones to aryl, heteroaryl, alkenyl, and alkyl imines, giving 3-substituted isoindolinones in 84-99 % ee and 50:50-91:9 d.r. (see scheme). © 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

引用

页码：7654 / 7657

页数：4

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