A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and 133Xe-SPECT

被引:35
作者
Schytz, Henrik W. [1 ,2 ]
Guo, Song [1 ,2 ]
Jensen, Lars T.
Kamar, Moshe [3 ]
Nini, Asaph [3 ]
Gress, Daryl R. [4 ]
Ashina, Messoud [1 ,2 ]
机构
[1] Univ Copenhagen, Danish Headache Ctr, DK-2600 Glostrup, Denmark
[2] Univ Copenhagen, Fac Hlth Sci, Glostrup Hosp, Dept Neurol, DK-2600 Glostrup, Denmark
[3] Ornim Med Ltd, Lod, Israel
[4] Univ Virginia, Dept Neurol & Neurosurg, Charlottesville, VA USA
关键词
Cerebral blood flow; Ultrasound tagged near infrared spectroscopy; (133)Xenon single photon emission computer tomography; Acetazolamide; Monitoring; NEAR-INFRARED SPECTROSCOPY; ACETAZOLAMIDE PROVOCATION; HEALTHY-VOLUNTEERS; OXYGEN-SATURATION; BRAIN; LIGHT; TOMOGRAPHY; HUMANS; TISSUE;
D O I
10.1007/s12028-012-9720-2
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and (133)Xenon single photon emission computer tomography (Xe-133-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P a parts per thousand currency sign 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P a parts per thousand currency sign 0.033) at 15 min, but not at 60 min (P a parts per thousand yen 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with Xe-133-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.
引用
收藏
页码:139 / 145
页数:7
相关论文
共 33 条
[1]   EFFECTS OF ACETAZOLAMIDE ON CEREBRAL ACID-BASE-BALANCE [J].
BICKLER, PE ;
LITT, L ;
BANVILLE, DL ;
SEVERINGHAUS, JW .
JOURNAL OF APPLIED PHYSIOLOGY, 1988, 65 (01) :422-427
[2]   Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy [J].
Boas, DA ;
Dale, AM ;
Franceschini, MA .
NEUROIMAGE, 2004, 23 :S275-S288
[3]   THE EFFECT OF ACETAZOLAMIDE ON REGIONAL CEREBRAL BLOOD OXYGENATION AT REST AND UNDER STIMULATION AS ASSESSED BY MRI [J].
BRUHN, H ;
KLEINSCHMIDT, A ;
BOECKER, H ;
MERBOLDT, KD ;
HANICKE, W ;
FRAHM, J .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1994, 14 (05) :742-748
[4]   A METHOD FOR CALCULATING REGIONAL CEREBRAL BLOOD-FLOW FROM EMISSION COMPUTED-TOMOGRAPHY OF INERT-GAS CONCENTRATIONS [J].
CELSIS, P ;
GOLDMAN, T ;
HENRIKSEN, L ;
LASSEN, NA .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1981, 5 (05) :641-645
[5]  
CHRISTENSEN MS, 1965, ACTA NEUROL SCAND, VS 41, P152
[6]   Cerebral blood flow and the injured brain: how should we monitor and manipulate it? [J].
Dagal, Armagan ;
Lam, Arthur M. .
CURRENT OPINION IN ANESTHESIOLOGY, 2011, 24 (02) :131-137
[7]   Bilateral near infrared spectroscopy in space-occupying middle cerebral artery stroke [J].
Damian, M. S. ;
Schlosser, R. .
NEUROCRITICAL CARE, 2007, 6 (03) :165-173
[8]   ACETAZOLAMIDE-INDUCED VASODILATION IN THE CAROTID VASCULAR BED IN HEALTHY-VOLUNTEERS [J].
DEMOLIS, P ;
CHALON, S ;
GIUDICELLI, JF .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1995, 26 (05) :841-844
[9]  
Griffiths PD, 2001, VASC MED, V6, P51
[10]   Noninvasive cerebral oximetry: is there light at the end of the tunnel? [J].
Highton, David ;
Elwell, Clare ;
Smith, Martin .
CURRENT OPINION IN ANESTHESIOLOGY, 2010, 23 (05) :576-581