Which 2D Material is Better for DNA Detection: Graphene, MoS2, or MXene?

被引：22

作者：

Cao, Zhonglin ^{[1
]}

Yadav, Prakarsh ^{[1
]}

Farimani, Amir Barati ^{[1
,2
,3
]}

机构：

[1] Carnegie Mellon Univ, Dept Mech Engn, Pittsburgh, PA 15213 USA

[2] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA

[3] Carnegie Mellon Univ, Dept Chem Engn, Pittsburgh, PA 15213 USA

来源：

NANO LETTERS | 2022年 / 22卷 / 19期

基金：

美国安德鲁·梅隆基金会;

关键词：

DNA detection; nanopore; 2D materials; graphene; MoS2; MXene; BASE IDENTIFICATION; MOLECULAR-DYNAMICS; ELECTRIC-FIELD; STRANDED-DNA; NANOPORE; SINGLE; TRANSLOCATIONS; POLYMERASE; RNA;

D O I：

10.1021/acs.nanolett.2c02603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite much research on characterizing 2D materials for DNA detection with nanopore technology, a thorou comparison between the performance of different 2D materials is currently lacking. In this work, using extensive molecular dynamics simulations, we compare nanoporous graphene, MoS2 and titanium carbide MXene (Ti3C2) for their DNA detection performance and sensitivity. The ionic current and residence time of DNA are characterized in each nanoporous materials by performing hundreds of simulations. We devised two statistical measures including the Kolmogorov-Smirnov test and the absolute pairwise difference to compare the performance of nanopores. We found that graphene nanopore is the most sensitive membrane for distinguishing DNA bases. The MoS2 is capable of distinguishing the A and T bases from the C and G bases better than graphene and MXene. Physisorption and the orientation of DNA in nanopores are further investigated to provide molecular insight into the performance characteristics of different nanopores.

引用

页码：7874 / 7881

页数：8

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