Interleukin-6 Gene Polymorphism in Febrile Seizures

被引：28

作者：

Nur, Banu Guzel ^{[2
]}

Kahramaner, Zelal ^{[3
]}

Duman, Ozgur ^{[1
]}

Dundar, Nihal Olgac ^{[4
]}

Sallakci, Nilgun ^{[5
]}

Yavuzer, Ugur ^{[6
]}

Haspolat, Senay ^{[1
]}

机构：

[1] Akdeniz Univ, Sch Med, Dept Pediat, Div Child Neurol, TR-07070 Antalya, Turkey

[2] Antalya Educ & Res Hosp, Dept Pediat, Antalya, Turkey

[3] Tepecik Educ & Res Hosp, Dept Pediat, Izmir, Turkey

[4] Suleyman Demirel Univ, Sch Med, Dept Child Neurol, TR-32200 Isparta, Turkey

[5] Akdeniz Univ, Sch Med, Dept Child Immunol, TR-07070 Antalya, Turkey

[6] Akdeniz Univ, Sch Med, Dept Physiol, TR-07070 Antalya, Turkey

来源：

PEDIATRIC NEUROLOGY | 2012年 / 46卷 / 01期

关键词：

RECEPTOR ANTAGONIST; ANTIINFLAMMATORY CYTOKINES; SUSCEPTIBILITY; CONVULSIONS; CHILDREN; ASSOCIATION;

D O I：

10.1016/j.pediatrneurol.2011.10.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Febrile seizures comprise a common type of pediatric convulsion. Inflammation and genetics may be involved in their pathogenesis. Regarding the role of cytokines (especially interleukin-6) in febrile responses, we performed a case control study of interleukin-6 gene (-174, -572, and -597) single-nucleotide polymorphisms to learn if correlations existed between these particular polymorphisms and febrile seizures. We isolated the genomic DNA of 92 children with febrile seizures and 98 healthy control subjects. We genotyped individuals for their polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism. In our study, the frequencies of 174 G alleles and of the 174 and 572 GG genotypes were observed to be significantly higher in patients than in control subjects. The 174 GG genotype frequency was significantly higher in children with a family history of febrile seizures. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：36 / 38

页数：3

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